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Letter: Non-Nutritive Sweeteners May Have a Bell-Shaped Dose Response for Dysbiosis-Related Adverse Effects That Contributed to Discrepancies between Prospective Cohort and Randomized Controlled Studies.

作者信息

Qin Xiaofa

机构信息

GI Biopharma Inc., Westfield, NJ, USA.

出版信息

J Obes Metab Syndr. 2020 Sep 30;29(3):237-239. doi: 10.7570/jomes20077.

DOI:10.7570/jomes20077
PMID:32908023
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7539341/
Abstract
摘要

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Microorganisms. 2022 Feb 14;10(2):434. doi: 10.3390/microorganisms10020434.

本文引用的文献

1
Non-nutritive Sweeteners and Their Associations with Obesity and Type 2 Diabetes.非营养性甜味剂及其与肥胖症和2型糖尿病的关联。
J Obes Metab Syndr. 2020 Jun 30;29(2):114-123. doi: 10.7570/jomes19079.
2
Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial.慢性摄入三氯蔗糖会导致年轻健康成年人血清胰岛素水平升高：一项随机、双盲、对照试验。
Nutr J. 2020 Apr 13;19(1):32. doi: 10.1186/s12937-020-00549-5.
3
Sucralose decreases insulin sensitivity in healthy subjects: a randomized controlled trial.三氯蔗糖降低健康受试者的胰岛素敏感性：一项随机对照试验。
Am J Clin Nutr. 2018 Sep 1;108(3):485-491. doi: 10.1093/ajcn/nqy152.
4
Saccharin Increases Fasting Blood Glucose but Not Liver Insulin Resistance in Comparison to a High Fructose-Fed Rat Model.甜蜜素会升高空腹血糖，但与高果糖喂养大鼠模型相比，不会引起肝脏胰岛素抵抗。
Nutrients. 2018 Mar 12;10(3):341. doi: 10.3390/nu10030341.
5
A 12-week randomized clinical trial investigating the potential for sucralose to affect glucose homeostasis.一项为期12周的随机临床试验，研究三氯蔗糖对葡萄糖稳态的影响潜力。
Regul Toxicol Pharmacol. 2017 Aug;88:22-33. doi: 10.1016/j.yrtph.2017.05.011. Epub 2017 May 11.
6
The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences.慢性摄入糖精对大鼠肝、胰腺功能和形态的影响：性别差异。
Bosn J Basic Med Sci. 2013 May;13(2):94-9. doi: 10.17305/bjbms.2013.2372.
7
Splenda alters gut microflora and increases intestinal p-glycoprotein and cytochrome p-450 in male rats.三氯蔗糖会改变雄性大鼠的肠道微生物群，并增加其肠道P-糖蛋白和细胞色素P-450。
J Toxicol Environ Health A. 2008;71(21):1415-29. doi: 10.1080/15287390802328630.
8
Synergic effect of bacterial glycosidases and digestive proteases on mucus degradation and the reduced risk of inflammatory bowel disease-like gut damage in both germ-free and poor hygiene conditions.
Inflamm Bowel Dis. 2008 Jan;14(1):145-6. doi: 10.1002/ibd.20274.
9
Evaluation of the dose response and in utero exposure to saccharin in the rat.
Food Chem Toxicol. 1985 Apr-May;23(4-5):475-90. doi: 10.1016/0278-6915(85)90142-5.