Gallo Alessia, Bulati Matteo, Miceli Vitale, Amodio Nicola, Conaldi Pier Giulio
Department of Research, IRCCS ISMETT (Istituto Mediterraneo per i Trapianti e Terapie ad alta specializzazione), Via E.Tricomi 5, 90127 Palermo, Italy.
Department of Experimental and Clinical Medicine, Magna Graecia University of Catanzaro, 88100 Catanzaro, Italy.
Noncoding RNA. 2020 Sep 10;6(3):38. doi: 10.3390/ncrna6030038.
The awareness of viruses as a constant threat for human public health is a matter of fact and in this resides the need of understanding the mechanisms they use to trick the host. Viral non-coding RNAs are gaining much value and interest for the potential impact played in host gene regulation, acting as fine tuners of host cellular defense mechanisms. The implicit importance of v-ncRNAs resides first in the limited genomes size of viruses carrying only strictly necessary genomic sequences. The other crucial and appealing characteristic of v-ncRNAs is the non-immunogenicity, making them the perfect expedient to be used in the never-ending virus-host war. In this review, we wish to examine how DNA and RNA viruses have evolved a common strategy and which the crucial host pathways are targeted through v-ncRNAs in order to grant and facilitate their life cycle.
病毒对人类公共卫生构成持续威胁，这是不争的事实，正因如此，我们有必要了解它们用来欺骗宿主的机制。病毒非编码RNA在宿主基因调控中发挥着潜在作用，作为宿主细胞防御机制的微调器，正变得越来越有价值且备受关注。病毒非编码RNA的潜在重要性首先在于携带仅严格必要基因组序列的病毒基因组大小有限。病毒非编码RNA的另一个关键且吸引人的特性是其非免疫原性，这使其成为在永无休止的病毒与宿主之战中使用的完美手段。在本综述中，我们希望探讨DNA病毒和RNA病毒如何演化出共同策略，以及病毒非编码RNA靶向哪些关键宿主途径以确保并促进其生命周期。
