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紫外线照射能提高羟基磷灰石的亲水性和骨传导性。

Ultraviolet irradiation improves the hydrophilicity and osteo-conduction of hydroxyapatite.

机构信息

Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan.

出版信息

J Orthop Surg Res. 2020 Sep 18;15(1):425. doi: 10.1186/s13018-020-01949-3.

DOI:10.1186/s13018-020-01949-3
PMID:32948233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7501630/
Abstract

BACKGROUND

Treating a titanium or titanium alloy implant with ultraviolet (UV) light is known to improve its associated cell growth and osseointegration. However, little is known about the effect of UV irradiation on hydroxyapatite (HA), which is also used frequently in orthopaedic and dental surgery. Here we examined the effect of UV irradiation on the hydrophilicity of HA, and on its osteoconduction ability in rats.

METHODS

HA implants of low and high porosity were treated with UV light, and photofunctionalisation was assessed by the contact angle of a water drop on the surface. HA implants were also inserted into rat femurs, and the rats were killed 2 or 4 weeks later. The bone volume and bone area ratio were calculated from microcomputed tomography and histological data.

RESULTS

The contact angle of a water drop on HA implants of both porosities was significantly reduced after UV irradiation. In the rat femurs, there was no significant difference in the bone volume between the UV light-treated and control implants at 2 or 4 weeks. The bone area ratio for the UV light-treated versus control implants was significantly increased at 2 weeks, but there was no significant difference at 4 weeks.

CONCLUSIONS

The surface of UV-irradiated HA disks was hydrophilic, in contrast to that of non-irradiated HA disks. Photofunctionalisation accelerated the increase in the bone area ratio in the early healing stage. This technology can be applied to surgical cases requiring the early fusion of bone and HA.

摘要

背景

用紫外线（UV）光处理钛或钛合金植入物已被证实能提高其相关细胞生长和骨整合。然而，对于羟基磷灰石（HA），其在骨科和牙科手术中也经常使用，但人们对其在紫外线照射下的影响知之甚少。在这里，我们研究了紫外线照射对 HA 亲水性的影响，以及对大鼠中骨传导能力的影响。

方法

用紫外线处理低孔隙率和高孔隙率的 HA 植入物，并通过水滴在表面上的接触角评估光功能化。HA 植入物也被插入大鼠股骨中，2 或 4 周后处死大鼠。从微计算机断层扫描和组织学数据计算骨体积和骨面积比。

结果

两种孔隙率的 HA 植入物在紫外线照射后水滴的接触角显著降低。在大鼠股骨中，在 2 或 4 周时，紫外线处理和对照植入物之间的骨体积没有显著差异。与对照植入物相比，UV 光处理的植入物的骨面积比在 2 周时显著增加，但在 4 周时没有显著差异。

结论

与未辐照的 HA 盘相比，UV 辐照的 HA 盘表面具有亲水性。光功能化加速了早期愈合阶段骨面积比的增加。这项技术可以应用于需要骨和 HA 早期融合的手术病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/3088752a9137/13018_2020_1949_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/e1d9b78e31ba/13018_2020_1949_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/478740d3d02d/13018_2020_1949_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/93c75d637f9e/13018_2020_1949_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/0c8014c00a4c/13018_2020_1949_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/144f6c2093ed/13018_2020_1949_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/6e2bc91fa2bf/13018_2020_1949_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/3088752a9137/13018_2020_1949_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/e1d9b78e31ba/13018_2020_1949_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/478740d3d02d/13018_2020_1949_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/93c75d637f9e/13018_2020_1949_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/0c8014c00a4c/13018_2020_1949_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/144f6c2093ed/13018_2020_1949_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/6e2bc91fa2bf/13018_2020_1949_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9420/7501630/3088752a9137/13018_2020_1949_Fig7_HTML.jpg

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Bone Regeneration of Hydroxyapatite with Granular Form or Porous Scaffold in Canine Alveolar Sockets.犬牙槽窝中颗粒状或多孔支架状羟基磷灰石的骨再生
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Effect on surface character and mechanical property of unsintered hydroxyapatite/poly-l-lactic acid (uHA/PLLA) material by UV treatment.紫外线处理对未烧结羟基磷灰石/聚左旋乳酸（uHA/PLLA）材料表面特性和力学性能的影响。
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