Alberius P, Klinge B, Sjögren S
J Craniomaxillofac Surg. 1987 Apr;15(2):63-7. doi: 10.1016/s1010-5182(87)80020-3.
The present study was designed to elucidate the reactions of cranial membranous bone to bone wax. In ten young rabbits, twenty parietal bone defects were created by drilling, the edges of which were partly extended using rongeur forceps to enable investigation of eventual thermal effects. Half of the marginal bone surrounding the lesions was covered by bone wax, the remainder serving as control. The animals were sacrificed 1 and 7 weeks after surgery, and block specimens prepared for light microscopy. Merely slight tissue reactions to the bone wax were discerned. Bony regeneration occurred mainly from the dura mater and the pericranium, but also from the bony rim. Reskeletalization was markedly impaired by the presence of bone wax. Heat generated by drilling caused reduced bone formation despite constant irrigation peroperatively. Clinical consequences are discussed.
本研究旨在阐明颅骨膜性骨对骨蜡的反应。在10只幼兔身上，通过钻孔制造了20处顶骨缺损，用咬骨钳部分扩大缺损边缘，以便研究可能的热效应。损伤周围一半的边缘骨用骨蜡覆盖，其余作为对照。术后1周和7周处死动物，制备块状标本用于光学显微镜检查。仅发现对骨蜡有轻微的组织反应。骨再生主要发生于硬脑膜和颅骨膜，也发生于骨边缘。骨蜡的存在明显阻碍了再骨化。尽管术中持续冲洗，但钻孔产生的热量导致骨形成减少。文中讨论了临床后果。
