苏丹喀土穆州人群包虫病流行状况及相关危险因素分析。
Prevalence of cystic echinococcosis and associated risk factors among humans in Khartoum State, Central Sudan.
机构信息
Echinococcosis Research Center, Zamzam University College, Khartoum, Sudan.
Department of Surgery, Faculty of Medicine, Al-Neelain University, Khartoum, Sudan.
出版信息
Int Health. 2021 Jul 3;13(4):327-333. doi: 10.1093/inthealth/ihaa059.
BACKGROUND
Hydatid disease or cystic echinococcosis (CE) is caused by the larval stages of the cestode parasite Echinococcus granulosus. The objectives of this study were to estimate the prevalence of seropositivity and to identify the risk factors associated with the disease among humans in Khartoum State, Central Sudan.
METHODS
A cross-sectional study was conducted between November 2017 and April 2018. A total of 305 randomly selected consenting participants from three localities were included in the current investigation using a multistage probability sampling method. An in-house enzyme-linked immunosorbent assay was used to detect immunoglobulin G antibodies to E. granulosus. The χ2 test and logistic regression analysis were used to determine the risk factors associated with CE seropositivity.
RESULTS
A seroprevalence of 6.5% (20/305) was recorded among humans in Khartoum State, Central Sudan. Age (odds ratio [OR] 16.61 [confidence interval {CI} 2.21 to 117.92], p=0.006), locality (OR 3.08 [CI 1.42 to 22.54], p=0.011) and contact with dogs (OR 2.34 [CI 0.026 to 0.646], p=0.013) were recorded as potential risk factors for seropositivity to CE in the study area.
CONCLUSIONS
The seroprevalence of CE (6.5%) is high among humans in Khartoum State, Central Sudan. Improved surveillance is necessary to optimize control and prevention strategies for CE as an important neglected zoonotic disease among the human population in the study area of Central Sudan.
背景
包虫病或囊型包虫病（CE）是由绦虫寄生虫细粒棘球绦虫的幼虫阶段引起的。本研究的目的是估计血清阳性率，并确定苏丹中部喀土穆州人群中与该病相关的危险因素。
方法
本研究采用横断面研究设计，于 2017 年 11 月至 2018 年 4 月期间进行。使用多阶段概率抽样方法，从三个地点随机选择 305 名同意参加的参与者纳入本研究。使用内部酶联免疫吸附试验检测抗细粒棘球绦虫 IgG 抗体。使用 χ2 检验和逻辑回归分析确定与 CE 血清阳性相关的危险因素。
结果
苏丹中部喀土穆州人群的血清阳性率为 6.5%（20/305）。年龄（比值比[OR] 16.61 [置信区间{CI} 2.21 至 117.92]，p=0.006）、地点（OR 3.08 [CI 1.42 至 22.54]，p=0.011）和与狗接触（OR 2.34 [CI 0.026 至 0.646]，p=0.013）被记录为该研究区域内对 CE 血清阳性的潜在危险因素。
结论
苏丹中部喀土穆州人群的 CE 血清阳性率（6.5%）较高。需要加强监测，以优化该地区人群中 CE 作为一种重要的被忽视的人畜共患病的控制和预防策略。
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