全氟和多氟烷基物质暴露、妊娠体重增加与 Viva 项目产后体重变化。
Per- and Polyfluoroalkyl Substance Exposure, Gestational Weight Gain, and Postpartum Weight Changes in Project Viva.
机构信息
Population Health Sciences Program, Harvard University, Boston, Massachusetts, USA.
Department of Epidemiology, Berkeley School of Public Health, University of California, Berkeley, California, USA.
出版信息
Obesity (Silver Spring). 2020 Oct;28(10):1984-1992. doi: 10.1002/oby.22933.
OBJECTIVE
The purpose of this study was to test the extent to which pregnancy per- and polyfluoroalkyl substance (PFAS) concentrations were associated with gestational weight gain and postpartum weight changes.
METHODS
This study was composed of 1,614 women recruited between 1999 and 2002 via the Project Viva cohort with pregnancy plasma concentrations of six PFAS, including perfluorooctanesulfonic acid, perfluorooctanoic acid (PFOA), and 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid. Gestational weight gain was defined as the difference between last pregnancy weight and prepregnancy weight, 1-year postpartum weight retention as the difference between 1-year postpartum weight and prepregnancy weight, and 3-year postpartum weight change as the difference between 3-year postpartum weight and prepregnancy weight.
RESULTS
During pregnancy, women gained 0.37 kg (95% CI: 0.11-0.62) more weight per doubling of 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid. At 1 year post partum, women retained 0.55 kg (95% CI: 0.07-1.04) more weight per doubling of PFOA. At 3 years post partum, women gained 0.91 kg (95% CI: 0.25-1.56) more weight per doubling in PFOA. Findings were similar after adjustment for all PFAS. Other PFAS were not associated with weight changes. Postpartum associations were stronger among women with higher prepregnancy BMI. Models were adjusted for demographics.
CONCLUSIONS
Pregnancy PFAS were associated with greater gestational weight gain, weight retention, and weight gain years after pregnancy.
目的
本研究旨在检验妊娠全氟和多氟烷基物质（PFAS）浓度与妊娠体重增加和产后体重变化的关联程度。
方法
这项研究由 1999 年至 2002 年期间通过 Project Viva 队列招募的 1614 名女性组成，她们的妊娠血浆中有六种 PFAS，包括全氟辛烷磺酸、全氟辛酸（PFOA）和 2-（N-乙基-全氟辛烷磺酰胺基）乙酸。妊娠体重增加定义为最后一次妊娠体重与妊娠前体重的差值，产后 1 年体重保留定义为产后 1 年体重与妊娠前体重的差值，产后 3 年体重变化定义为产后 3 年体重与妊娠前体重的差值。
结果
在妊娠期间，女性的体重每增加一倍 2-（N-乙基-全氟辛烷磺酰胺基）乙酸，体重就会增加 0.37 公斤（95%置信区间：0.11-0.62）。产后 1 年，女性的 PFOA 每增加一倍，体重就会增加 0.55 公斤（95%置信区间：0.07-1.04）。产后 3 年，女性的 PFOA 每增加一倍，体重就会增加 0.91 公斤（95%置信区间：0.25-1.56）。调整所有 PFAS 后，结果仍然相似。其他 PFAS 与体重变化无关。在孕前 BMI 较高的女性中，产后的关联更为强烈。模型调整了人口统计学因素。
结论
妊娠 PFAS 与妊娠体重增加、产后体重保留和产后数年体重增加有关。
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