Department of Otolaryngology, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
The Ohio State University College of Medicine, Columbus, OH, USA.
Ann Otol Rhinol Laryngol. 2021 Apr;130(4):395-404. doi: 10.1177/0003489420959692. Epub 2020 Sep 25.
In tissue engineering, biomaterials create a 3D scaffold for cell-to-cell adhesion, proliferation and tissue formation. Because of their similarity to extracellular matrix and architectural adaptability, nanofibers are of particular interest in tissue engineering. Electrospinning is a well-documented technique for nanofiber production for tissue engineering scaffolds. Here we present literature on the applications of electrospinning in the field of otolaryngology.
A PubMed database search was performed to isolate articles published about applications of electrospun nanofibers for tissue engineering in otolaryngology. Study design, size, material tested, site of application within the head and neck, and outcomes were obtained for each study.
Almost all data on electrospinning in otolaryngology was published in the last 6 years (84%), highlighting its novelty. A total of 25 pre-clinical studies were identified: 9 in vitro studies, 5 in vivo animal studies, and 11 combination studies. Sites of application included: tracheal reconstruction (n = 16), tympanic membrane repair (n = 3), cranial nerve regeneration (n = 3), mastoid osteogenesis (n = 1) and ear/nose chondrogenesis (n = 2).
Tissue engineering is a burgeoning field, with recent innovative applications in the field of otolaryngology. Electrospun nanofibers specifically have relevant applications in the field of otolaryngology, due in part to their similarity to native extracellular matrix, with emerging areas of interest being tympanic membrane repair, cranial nerve regeneration and tracheal reconstruction.
在组织工程中，生物材料为细胞间的黏附、增殖和组织形成创造了一个 3D 支架。由于其与细胞外基质的相似性和结构适应性，纳米纤维在组织工程中特别受到关注。静电纺丝是一种用于组织工程支架的纳米纤维生产的成熟技术。本文介绍了静电纺丝在耳鼻喉科领域的应用文献。
对PubMed 数据库进行了检索，以分离有关静电纺纳米纤维在耳鼻喉科组织工程中应用的文章。获取了每项研究的设计方案、大小、测试材料、在头颈部的应用部位和结果。
耳鼻喉科中几乎所有关于静电纺丝的研究数据都是在过去 6 年中发表的（84%），这突出了它的新颖性。共确定了 25 项临床前研究：9 项体外研究、5 项体内动物研究和 11 项联合研究。应用部位包括：气管重建（n=16）、鼓膜修复（n=3）、颅神经再生（n=3）、乳突成骨（n=1）和耳部/鼻部软骨生成（n=2）。
组织工程是一个新兴领域，最近在耳鼻喉科领域有了创新的应用。静电纺纳米纤维特别在耳鼻喉科领域有相关的应用，部分原因是它们与天然细胞外基质相似，新兴的研究领域包括鼓膜修复、颅神经再生和气管重建。
