Rudders R A
Blood. 1976 Feb;47(2):229-35.
We have defined two subpopulations of B lymphocytes in chronic lymphocytic leukemia (CLL). The major variant (termed typical) was characterized by the presence of a relatively homogeneous population of small-to-medium-sized lymphocytes with low-density SmIgM and no evidence of intracellular Ig synthesis. A minor group (termed atypical) was identified by the presence of a pleomorphic cell population with few small lymphocytes. The predominant SmIg was IgG, which was detected intracellularly as well as in the serum. The atypical group appeared to be an arrest at a later stage of differentiation where a switch from IgM to IgG synthesis and secretion had occurred. Clinical correlation suggested several clear-cut differences in clinicopathologic characteristics, but the median survivals for both groups at 2 yr was nearly identical.
我们已经在慢性淋巴细胞白血病（CLL）中定义了两个B淋巴细胞亚群。主要变体（称为典型型）的特征是存在相对均一的中小淋巴细胞群体，其表面免疫球蛋白M（SmIgM）密度低，且无细胞内免疫球蛋白合成的证据。一个较小的群体（称为非典型型）通过存在少量小淋巴细胞的多形性细胞群体来识别。主要的表面免疫球蛋白是免疫球蛋白G（IgG），在细胞内和血清中均能检测到。非典型群体似乎是在分化后期的停滞阶段，此时已发生从IgM合成和分泌到IgG合成和分泌的转换。临床相关性表明在临床病理特征上有几个明显的差异，但两组的2年中位生存期几乎相同。
