Stegink L D
Am J Clin Nutr. 1987 Jul;46(1 Suppl):204-15. doi: 10.1093/ajcn/46.1.204.
Toxicology is based on the premise that all compounds are toxic at some dose. Thus, it is not surprising that very large doses of aspartame (or its components--aspartate, phenylalanine, and methanol) produce deleterious effects in sensitive animal species. The critical question is whether aspartame ingestion is potentially harmful to humans at normal use and potential abuse levels. This paper reviews clinical studies testing the effects of various doses of aspartame upon blood levels of aspartate, phenylalanine, and methanol. These studies demonstrate that blood levels of these compounds are well below levels associated with adverse effects in sensitive animal species.
毒理学基于这样一个前提，即所有化合物在一定剂量下都是有毒的。因此，大剂量的阿斯巴甜（或其成分——天冬氨酸、苯丙氨酸和甲醇）在敏感动物物种中产生有害影响也就不足为奇了。关键问题是，在正常使用和潜在滥用水平下，摄入阿斯巴甜对人类是否有潜在危害。本文综述了测试不同剂量阿斯巴甜对天冬氨酸、苯丙氨酸和甲醇血液水平影响的临床研究。这些研究表明，这些化合物的血液水平远低于与敏感动物物种不良反应相关的水平。
