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衰老及衰老相关疾病中的细胞外囊泡与细胞外RNA

Extracellular vesicles and extracellular RNA in aging and age-related disease.

作者信息

Noren Hooten Nicole

机构信息

Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, 251 Bayview Boulevard, Baltimore, MD, 21224, USA.

出版信息

Transl Med Aging. 2020;4:96-98. doi: 10.1016/j.tma.2020.07.006. Epub 2020 Jul 24.

DOI:10.1016/j.tma.2020.07.006
PMID:33005835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7526621/
Abstract

Circulating factors are well known to influence aging and age-related disease. As part of the Aging Science Talks: Science for the Community series, data was presented on two types of circulating functional biomarkers: extracellular RNA (exRNA) and extracellular vesicles (EVs). EVs in the context of type 2 diabetes mellitus was also discussed, as this is an area of interest due to the growing global epidemic of this age-related disease.

摘要

众所周知,循环因子会影响衰老及与年龄相关的疾病。作为“衰老科学讲座:面向社区的科学”系列活动的一部分,会上展示了关于两种循环功能性生物标志物的数据:细胞外RNA(exRNA)和细胞外囊泡(EV)。会上还讨论了2型糖尿病背景下的细胞外囊泡,鉴于这种与年龄相关的疾病在全球范围内日益流行,这是一个备受关注的领域。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba8c/7526621/cbf1ec4ed6b1/nihms-1631631-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba8c/7526621/97aa78af9cca/nihms-1631631-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba8c/7526621/cbf1ec4ed6b1/nihms-1631631-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba8c/7526621/97aa78af9cca/nihms-1631631-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ba8c/7526621/cbf1ec4ed6b1/nihms-1631631-f0002.jpg

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Am J Physiol Cell Physiol. 2020 Jun 1;318(6):C1189-C1199. doi: 10.1152/ajpcell.00536.2019. Epub 2020 Apr 29.
2
The biology function and biomedical applications of exosomes.外泌体的生物学功能和生物医学应用。
Science. 2020 Feb 7;367(6478). doi: 10.1126/science.aau6977.
3
Extracellular RNA profiles with human age.细胞外 RNA 谱与人类年龄。
Cell Rep. 2024 Sep 24;43(9):114721. doi: 10.1016/j.celrep.2024.114721. Epub 2024 Sep 9.
4
Integrins are enriched on aberrantly fucosylated tumour-derived urinary extracellular vesicles.整合素在异常岩藻糖基化的肿瘤来源的尿液细胞外囊泡中富集。
J Extracell Biol. 2022 Oct 10;1(10):e64. doi: 10.1002/jex2.64. eCollection 2022 Oct.
5
Targeting Extracellular RNA Mitigates Hepatic Lipotoxicity and Liver Injury in NASH.靶向细胞外 RNA 可减轻 NASH 的肝脂肪毒性和肝损伤。
Cells. 2023 Jul 13;12(14):1845. doi: 10.3390/cells12141845.
6
Effect of Genetic Factors, Age and Sex on Levels of Circulating Extracellular Vesicles and Platelets.遗传因素、年龄和性别对循环细胞外囊泡和血小板水平的影响。
Int J Mol Sci. 2023 Apr 13;24(8):7183. doi: 10.3390/ijms24087183.
7
Multifaceted roles of extracellular RNAs in different diseases.细胞外 RNA 在不同疾病中的多方面作用。
Mil Med Res. 2022 Aug 11;9(1):43. doi: 10.1186/s40779-022-00405-z.
8
Influences of age, race, and sex on extracellular vesicle characteristics.年龄、种族和性别对细胞外囊泡特征的影响。
Theranostics. 2022 May 24;12(9):4459-4476. doi: 10.7150/thno.72676. eCollection 2022.
9
Research progress of extracellular vesicles in type 2 diabetes and its complications.细胞外囊泡在 2 型糖尿病及其并发症中的研究进展。
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10
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Front Pharmacol. 2021 Nov 10;12:773844. doi: 10.3389/fphar.2021.773844. eCollection 2021.
Aging Cell. 2018 Aug;17(4):e12785. doi: 10.1111/acel.12785. Epub 2018 May 24.
4
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5
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.2 型糖尿病及其并发症的全球病因学和流行病学。
Nat Rev Endocrinol. 2018 Feb;14(2):88-98. doi: 10.1038/nrendo.2017.151. Epub 2017 Dec 8.
6
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7
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Sci Rep. 2017 May 2;7(1):1342. doi: 10.1038/s41598-017-01386-z.
8
Extracellular RNA in aging.衰老过程中的细胞外RNA
Wiley Interdiscip Rev RNA. 2017 Mar;8(2). doi: 10.1002/wrna.1385. Epub 2016 Aug 17.
9
Biological properties of extracellular vesicles and their physiological functions.细胞外囊泡的生物学特性及其生理功能。
J Extracell Vesicles. 2015 May 14;4:27066. doi: 10.3402/jev.v4.27066. eCollection 2015.
10
Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.外泌体和其他细胞外囊泡的生物发生、分泌和细胞间相互作用。
Annu Rev Cell Dev Biol. 2014;30:255-89. doi: 10.1146/annurev-cellbio-101512-122326. Epub 2014 Aug 21.