• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

掺有人参皂苷Rg1/明胶微球的锶改性半水硫酸钙支架用于骨再生

Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration.

作者信息

Luo Peng, Yu Lan, Lin Qiang, Wang Changde, Yang Dazhi, Tang Shuo

机构信息

Department of Orthopaedics, Huazhong University of Science and Technology Union Shenzhen Hospital (Nanshan Hospital), Shenzhen, China.

Department of Orthopaedics, The 6th Affiliated Hospital of Shenzhen University Health Science Center, Shenzhen, China.

出版信息

Front Bioeng Biotechnol. 2020 Aug 18;8:888. doi: 10.3389/fbioe.2020.00888. eCollection 2020.

DOI:10.3389/fbioe.2020.00888
PMID:33014995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7461947/
Abstract

The aim of this study was to prepare a promising biomaterial for bone tissue repair and regeneration. The Strontium - calcium sulfate hemihydrate (Sr-α-CaS) scaffold incorporating gelatin microspheres (GMs) encapsulated with Ginsenoside Rg1 (Rg1) was designed. The scaffolds of Rg1/GMs/Sr-α-CaS showed sustained release of Rg1, good biocompatibility and ability of promoting osteogenic differentiation and angiogenesis . The scaffolds were implanted into animal model of cranial bone defect to characterize bone tissue repair and regeneration . From the images of Micro-CT, it was obvious that the most bone tissue was formed in Rg1/GMs/Sr-α-CaS group in 12 weeks. New bone structure, collagen and mineralization were analyzed with staining of HE, Masson and Safranin O-Fast green and showed good distribution. The expression of osteocalcin of Rg1/GMs/Sr-α-CaS indicated new bone formation in defect site. The results revealed that synergy of Rg1 and Sr showed the best effect of bone repair and regeneration, which provided a new candidate for bone defect repair in clinic.

摘要

本研究的目的是制备一种用于骨组织修复和再生的有前景的生物材料。设计了一种包含包裹人参皂苷Rg1（Rg1）的明胶微球（GMs）的半水硫酸锶钙（Sr-α-CaS）支架。Rg1/GMs/Sr-α-CaS支架表现出Rg1的持续释放、良好的生物相容性以及促进成骨分化和血管生成的能力。将该支架植入颅骨缺损动物模型以表征骨组织的修复和再生情况。从显微CT图像可以明显看出，在12周时，Rg1/GMs/Sr-α-CaS组形成的骨组织最多。通过苏木精-伊红（HE）染色、马松（Masson）染色和番红O-固绿染色对新骨结构、胶原蛋白和矿化进行分析，结果显示分布良好。Rg1/GMs/Sr-α-CaS组骨钙素的表达表明缺损部位有新骨形成。结果表明，Rg1和Sr的协同作用对骨修复和再生显示出最佳效果，为临床骨缺损修复提供了一种新的候选材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/e5231ebd40ac/fbioe-08-00888-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/003d4ba863b9/fbioe-08-00888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/60a0914b2844/fbioe-08-00888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/7ccfb05c7e04/fbioe-08-00888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/663ff215cf33/fbioe-08-00888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/419ccff68a59/fbioe-08-00888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/bca8fa5e7779/fbioe-08-00888-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/6948e33bb8c4/fbioe-08-00888-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/e5231ebd40ac/fbioe-08-00888-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/003d4ba863b9/fbioe-08-00888-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/60a0914b2844/fbioe-08-00888-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/7ccfb05c7e04/fbioe-08-00888-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/663ff215cf33/fbioe-08-00888-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/419ccff68a59/fbioe-08-00888-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/bca8fa5e7779/fbioe-08-00888-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/6948e33bb8c4/fbioe-08-00888-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0c91/7461947/e5231ebd40ac/fbioe-08-00888-g008.jpg

相似文献

1
Strontium Modified Calcium Sulfate Hemihydrate Scaffold Incorporating Ginsenoside Rg1/Gelatin Microspheres for Bone Regeneration.掺有人参皂苷Rg1/明胶微球的锶改性半水硫酸钙支架用于骨再生
Front Bioeng Biotechnol. 2020 Aug 18;8:888. doi: 10.3389/fbioe.2020.00888. eCollection 2020.
2
Multi-stage controllable degradation of strontium-doped calcium sulfate hemihydrate-tricalcium phosphate microsphere composite as a substitute for osteoporotic bone defect repairing: degradation behavior and bone response.锶掺杂半水硫酸钙-磷酸三钙微球复合材料的多阶段可控降解作为骨质疏松性骨缺损修复的替代物：降解行为和骨反应。
Biomed Mater. 2021 Dec 29;17(1). doi: 10.1088/1748-605X/ac4323.
3
A Naringin-loaded gelatin-microsphere/nano-hydroxyapatite/silk fibroin composite scaffold promoted healing of critical-size vertebral defects in ovariectomised rat.一种负载柚皮苷的明胶微球/纳米羟基磷灰石/丝素蛋白复合支架促进去卵巢大鼠临界尺寸椎体缺损的愈合。
Int J Biol Macromol. 2021 Dec 15;193(Pt A):510-518. doi: 10.1016/j.ijbiomac.2021.10.036. Epub 2021 Oct 25.
4
In vitro evaluation of Panax notoginseng Rg1 released from collagen/chitosan-gelatin microsphere scaffolds for angiogenesis.体外评价三七总皂苷 Rg1 从胶原蛋白/壳聚糖-明胶微球支架中释放促进血管生成。
Biomed Eng Online. 2013 Dec 31;12:134. doi: 10.1186/1475-925X-12-134.
5
Bioactive strontium ions/ginsenoside Rg1-incorporated biodegradable silk fibroin-gelatin scaffold promoted challenging osteoporotic bone regeneration.负载生物活性锶离子/人参皂苷Rg1的可生物降解丝素蛋白-明胶支架促进了具有挑战性的骨质疏松性骨再生。
Mater Today Bio. 2021 Sep 28;12:100141. doi: 10.1016/j.mtbio.2021.100141. eCollection 2021 Sep.
6
Sr-HA scaffolds fabricated by SPS technology promote the repair of segmental bone defects.SPS 技术制备的 Sr-HA 支架促进节段性骨缺损的修复。
Tissue Cell. 2020 Oct;66:101386. doi: 10.1016/j.tice.2020.101386. Epub 2020 May 20.
7
Strontium-substituted calcium sulfate hemihydrate/hydroxyapatite scaffold enhances bone regeneration by recruiting bone mesenchymal stromal cells.锶取代的硫酸钙半水合物/羟基磷灰石支架通过募集骨髓间充质基质细胞增强骨再生。
J Biomater Appl. 2020 Jul;35(1):97-107. doi: 10.1177/0885328220915816. Epub 2020 Mar 31.
8
A novel resorbable strontium-containing α-calcium sulfate hemihydrate bone substitute: a preparation and preliminary study.一种新型可吸收含锶半水硫酸钙α骨替代物：制备及初步研究
Biomed Mater. 2014 Aug;9(4):045010. doi: 10.1088/1748-6041/9/4/045010. Epub 2014 Jul 16.
9
BMP-2-releasing gelatin microspheres/PLGA scaffolds for bone repairment of X-ray-radiated rabbit radius defects.载 BMP-2 明胶微球/PLGA 支架修复兔桡骨放射性骨缺损。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1662-1673. doi: 10.1080/21691401.2019.1594852.
10
Controlled degradation of chitosan-coated strontium-doped calcium sulfate hemihydrate composite cement promotes bone defect repair in osteoporosis rats.壳聚糖包覆锶掺杂半水硫酸钙复合水泥的控制降解促进骨质疏松症大鼠骨缺损修复。
Biomed Mater. 2020 Sep 8;15(5):055039. doi: 10.1088/1748-605X/ab9fcf.

引用本文的文献

1
An injectable calcium sulfate-monetite biphasic cement for the treatment of critical-sized calvarial defects.一种用于治疗临界尺寸颅骨缺损的可注射硫酸钙-磷酸二氢钙双相骨水泥。
J Mater Sci Mater Med. 2025 Jul 29;36(1):61. doi: 10.1007/s10856-025-06911-5.
2
Biomimetic, biodegradable and osteoinductive treated dentin matrix/α-calcium sulphate hemihydrate composite material for bone tissue engineering.用于骨组织工程的仿生、可生物降解且具有骨诱导性的处理牙本质基质/半水硫酸钙复合材料
Regen Biomater. 2023 Jun 19;10:rbad061. doi: 10.1093/rb/rbad061. eCollection 2023.
3
Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration.

本文引用的文献

1
Controlled Release of BMP-2 from a Heparin-Conjugated Strontium-Substituted Nanohydroxyapatite/Silk Fibroin Scaffold for Bone Regeneration.肝素共轭锶取代纳米羟基磷灰石/丝素蛋白支架对骨形态发生蛋白-2的可控释放用于骨再生
ACS Biomater Sci Eng. 2018 Sep 10;4(9):3291-3303. doi: 10.1021/acsbiomaterials.8b00459. Epub 2018 Aug 9.
2
Bibliographic review on the state of the art of strontium and zinc based regenerative therapies. Recent developments and clinical applications.文献回顾：锶和锌基再生疗法的最新进展和临床应用。
J Mater Chem B. 2019 Mar 28;7(12):1974-1985. doi: 10.1039/c8tb02738b. Epub 2019 Feb 27.
3
锶功能化生物材料用于骨再生的研究进展
Bioengineering (Basel). 2023 Mar 26;10(4):414. doi: 10.3390/bioengineering10040414.
4
Traditional Chinese Medicine Compound-Loaded Materials in Bone Regeneration.用于骨再生的中药复方负载材料
Front Bioeng Biotechnol. 2022 Feb 18;10:851561. doi: 10.3389/fbioe.2022.851561. eCollection 2022.
5
Bioactive Herbal Extracts of Traditional Chinese Medicine Applied with the Biomaterials: For the Current Applications and Advances in the Musculoskeletal System.应用于生物材料的中药生物活性提取物：在肌肉骨骼系统中的当前应用与进展
Front Pharmacol. 2021 Oct 28;12:778041. doi: 10.3389/fphar.2021.778041. eCollection 2021.
Strontium‑containing α‑calcium sulfate hemihydrate promotes bone repair via the TGF‑β/Smad signaling pathway.
含锶的 α-半水硫酸钙通过 TGF-β/Smad 信号通路促进骨修复。
Mol Med Rep. 2019 Oct;20(4):3555-3564. doi: 10.3892/mmr.2019.10592. Epub 2019 Aug 20.
4
Reconstruction of large segmental bone defects in rabbit using the Masquelet technique with α-calcium sulfate hemihydrate.应用 α-半水硫酸钙骨水泥的 Masquelet 技术重建兔大段骨缺损。
J Orthop Surg Res. 2019 Jun 26;14(1):192. doi: 10.1186/s13018-019-1235-5.
5
Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro.体外实验中，人参皂苷 Rg1 以剂量依赖的方式加速人乳腺脂肪来源干细胞的旁分泌活性和脂肪生成分化。
Cell Transplant. 2019 Mar;28(3):286-295. doi: 10.1177/0963689719825615. Epub 2019 Jan 24.
6
Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation.人参皂苷Rg1调节内侧前额叶皮层放电并抑制海马-内侧前额叶皮层长时程增强。
J Ginseng Res. 2018 Jul;42(3):298-303. doi: 10.1016/j.jgr.2017.03.010. Epub 2017 Apr 4.
7
Molecular signaling of ginsenosides Rb1, Rg1, and Rg3 and their mode of actions.人参皂苷Rb1、Rg1和Rg3的分子信号传导及其作用方式。
J Ginseng Res. 2018 Apr;42(2):123-132. doi: 10.1016/j.jgr.2017.01.008. Epub 2017 Jan 19.
8
Ginsenoside Rg1 protects rat bone marrow mesenchymal stem cells against ischemia induced apoptosis through miR-494-3p and ROCK-1.人参皂苷 Rg1 通过 miR-494-3p 和 ROCK-1 保护大鼠骨髓间充质干细胞免受缺血诱导的细胞凋亡。
Eur J Pharmacol. 2018 Mar 5;822:154-167. doi: 10.1016/j.ejphar.2018.01.001. Epub 2018 Jan 4.
9
Effects of ginsenoside‑Rg1 on the proliferation and glial‑like directed differentiation of embryonic rat cortical neural stem cells in vitro.人参皂苷 Rg1 对体外培养的大鼠胚胎皮质神经干细胞增殖和胶质样定向分化的影响。
Mol Med Rep. 2017 Dec;16(6):8875-8881. doi: 10.3892/mmr.2017.7737. Epub 2017 Oct 6.
10
Hydroxyapatite-polymer biocomposites for bone regeneration: A review of current trends.羟基磷灰石-聚合物生物复合材料在骨再生中的应用：当前趋势综述。
J Biomed Mater Res B Appl Biomater. 2018 Jul;106(5):2046-2057. doi: 10.1002/jbm.b.33950. Epub 2017 Jun 26.