Holland C S
Br J Oral Maxillofac Surg. 1987 Aug;25(4):293-9. doi: 10.1016/0266-4356(87)90068-4.
This study compares the influence of methylprednisolone with that of a placebo on post-operative pain and swelling, and on healing. Twenty patients undergoing the removal of symmetrically placed bilateral lower third molar teeth under local analgesia by the same operator one side at a time were used. In each individual patient, for one side 40 mg methylprednisolone (Solumedrone Upjohn Limited) was given intravenously immediately preoperatively and for the other side a placebo was given on a double-blind random basis. The results showed that the mean post-operative swelling at 24 hours was reduced by 56% (p = .0003) when methylprednisolone was used compared with the opposite side of the same patient when the placebo was used. The severity of pain also was reduced over the first day but healing was similar for each side. Sixteen patients indicated a preference for the overall post-operative course when methylprednisolone was used.
本研究比较了甲基泼尼松龙与安慰剂对术后疼痛、肿胀及愈合的影响。选取了20例患者，由同一名操作者在局部麻醉下一次拔除一侧对称放置的双侧下颌第三磨牙。在每位患者中，一侧在术前即刻静脉注射40mg甲基泼尼松龙（索纳得龙，Upjohn有限公司），另一侧则以双盲随机方式给予安慰剂。结果显示，与使用安慰剂时同一患者的对侧相比，使用甲基泼尼松龙时24小时的平均术后肿胀减少了56%（p = 0.0003）。术后第一天疼痛程度也有所减轻，但两侧愈合情况相似。16例患者表示使用甲基泼尼松龙时更倾向于整体术后过程。
