Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran.
Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran.
Int J Nanomedicine. 2020 Sep 24;15:7063-7078. doi: 10.2147/IJN.S263238. eCollection 2020.
The importance of timely diagnosis and the complete treatment of lung cancer for many people with this deadly disease daily increases due to its high mortality. Diagnosis and treatment with helping the nanoparticles are useful, although they have reasonable harms. This article points out that the side effects of using carbon nanotube (CNT) in this disease treatment process such as inflammation, fibrosis, and carcinogenesis are very problematic. Toxicity can reduce to some extent using the techniques such as functionalizing to proper dimensions as a longer length, more width, and greater curvature. The targeted CNT sensors can be connected to various modified vapors. In this regard, with helping this method, screening makes non-invasive diagnosis possible. Researchers have also found that nanoparticles such as CNTs could be used as carriers to direct drug delivery, especially with chemotherapy drugs. Most of these carriers were multi-wall carbon nanotubes (MWCNT) used for cancerous cell targeting. The results of laboratory and animal researches in the field of diagnosis and treatment became very desirable and hopeful. The collection of researches summarized has highlighted the requirement for a detailed assessment which includes CNT dose, duration, method of induction, etc., to achieve the most controlled conditions for animal and human studies. In the discussion section, 4 contradictory issues are discussed which are invited researchers to do more research to get clearer results.
由于肺癌死亡率高，对于许多患有这种致命疾病的人来说，及时诊断和完成治疗变得至关重要。尽管纳米粒子的帮助具有合理的危害，但诊断和治疗仍然是有用的。本文指出，在治疗过程中使用碳纳米管（CNT）会产生一些副作用，如炎症、纤维化和致癌性，这些副作用非常成问题。通过将其功能化到适当的尺寸，如更长的长度、更宽的宽度和更大的曲率，可以在一定程度上降低毒性。靶向 CNT 传感器可以与各种改性蒸气连接。在这方面，借助这种方法，可以进行非侵入性诊断。研究人员还发现，纳米粒子（如 CNT）可被用作载体来定向药物输送，特别是化疗药物。这些载体大多是多壁碳纳米管（MWCNT），用于靶向癌细胞。诊断和治疗领域的实验室和动物研究结果非常理想和有希望。综述的研究结果强调需要进行详细评估，包括 CNT 剂量、持续时间、诱导方法等，以在动物和人类研究中实现最受控的条件。在讨论部分，讨论了 4 个有争议的问题，邀请研究人员进行更多的研究以获得更清晰的结果。
