Population Health Research Institute, St George's University of London, London, England, UK.
The Medical Examiners' Service, St George's University Hospitals NHS Foundation Trust, London, England, UK.
BMJ Open. 2020 Oct 16;10(10):e040638. doi: 10.1136/bmjopen-2020-040638.
To undertake a case review of deaths in a 6-week period during the COVID-19 pandemic commencing with the first death in the hospital from COVID-19 on 12th of March 2020 and contrast this with the same period in 2019.
A large London teaching hospital.
Three groups were compared: group 1-COVID-19-associated deaths in the 6-week period (n=243), group 2-non-COVID deaths in the same period (n=136) and group 3-all deaths in a comparison period of the same 6 weeks in 2019 (n=194).
This was a descriptive analysis of death case series review and as such no primary or secondary outcomes were pre-stipulated.
Deaths in patients from the Black, Asian and minority ethnic (BAME) communities in the pandemic period significantly increased both in the COVID-19 group (OR=2.43, 95% CI=1.60-3.68, p<0.001) and the non-COVID group (OR=1.76, 95% CI=1.09-2.83, p=0.02) during this time period and the increase was independent of differences in comorbidities, sex, age or deprivation. While the absolute number of deaths increased in 2020 compared with 2019, across all three groups the distribution of deaths by age was very similar. Our analyses confirm major risk factors for COVID-19 mortality including male sex, diabetes, having multiple comorbidities and background from the BAME communities.
There was no evidence of COVID-19 deaths occurring disproportionately in the elderly compared with non-COVID deaths in this period in 2020 and 2019. Deaths in the BAME communities were over-represented in both COVID-19 and non-COVID groups, highlighting the need for detailed research in order to fully understand the influence of ethnicity on susceptibility to illness, mortality and health-seeking behaviour during the pandemic.
对 2020 年 3 月 12 日医院首例 COVID-19 死亡病例开始的 6 周期间的死亡病例进行回顾性分析,并与 2019 年同期进行对比。
伦敦一家大型教学医院。
将 3 组进行对比:第 1 组为 COVID-19 相关的 6 周死亡病例(n=243),第 2 组为同期非 COVID 死亡病例(n=136),第 3 组为 2019 年同期 6 周的所有死亡病例(n=194)。
这是一项死亡病例系列回顾的描述性分析,因此没有预先规定主要或次要结果。
在 COVID-19 组(OR=2.43,95%CI=1.60-3.68,p<0.001)和非 COVID 组(OR=1.76,95%CI=1.09-2.83,p=0.02)中,来自黑人、亚洲和少数族裔(BAME)社区的患者在大流行期间的死亡人数显著增加,这种增加独立于合并症、性别、年龄或贫困程度的差异。虽然 2020 年的死亡绝对人数较 2019 年有所增加,但在所有 3 组中,年龄分布的死亡情况非常相似。我们的分析证实了 COVID-19 死亡率的主要危险因素,包括男性、糖尿病、患有多种合并症和来自 BAME 社区。
在 2020 年和 2019 年同期,没有证据表明 COVID-19 死亡人数与非 COVID 死亡人数不成比例地集中在老年人中。BAME 社区的死亡人数在 COVID-19 和非 COVID 组中均占多数,这突显了需要进行详细研究,以充分了解种族对疾病易感性、死亡率和大流行期间寻求医疗服务行为的影响。