State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China.
State Key Laboratory of Biobased Material and Green Papermaking (LBMP), Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China.
Fitoterapia. 2020 Nov;147:104757. doi: 10.1016/j.fitote.2020.104757. Epub 2020 Oct 16.
Steriods which are ubiquitous in natural resources are important components of cell membranes and involved in several physiological functions. Steriods not only exerted the anticancer activity through inhibition of various enzymes and receptors in cancer cells, inclusive of aromatase, sulfatase, 5α-reductase, hydroxysteroid dehydrogenase and CYP 17, but also exhibited potential activity against various cancer forms including multidrug-resistant cancer with low cytotoxicity, and high bioavailability. Accordingly, steroids are useful scaffolds for the discovery of novel anticancer agents. This review aims to outline the advances of nature-derived steroids outside cardica glycosides with anticancer potential, covering the articles published between Jan. 2015 and Aug. 2020.
甾体化合物在自然资源中无处不在，是细胞膜的重要组成部分，并参与多种生理功能。甾体化合物不仅通过抑制癌细胞中的各种酶和受体（包括芳香酶、硫酸酯酶、5α-还原酶、羟甾类脱氢酶和 CYP17）发挥抗癌活性，而且还对多种癌症形式表现出潜在的活性，包括具有低细胞毒性和高生物利用度的多药耐药性癌症。因此，甾体化合物是发现新型抗癌药物的有用支架。本综述旨在概述具有潜在抗癌作用的非心脏糖苷的天然衍生甾体化合物的研究进展，涵盖了 2015 年 1 月至 2020 年 8 月期间发表的文章。
