Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.
Fujian Province Universities and Colleges Engineering Research Center for Marine Biomedical Resource Utilization, Xiamen Medical College, 1999 Guankouzhong Road, Xiamen 361023, China.
Bioorg Chem. 2020 Dec;105:104349. doi: 10.1016/j.bioorg.2020.104349. Epub 2020 Oct 8.
Ten new C polyketides (asperochratides A-J, 1-10) and 14 known miscellaneous compounds (11-24) were isolated from the deep-sea-derived fungus Aspergillus ochraceus. Structures of the new compounds were elucidated by extensive spectroscopic analyses, modified Mosher's method, Mo(OAc) induced circular dichroism (ICD) experiments, and ECD calculations. Structurally, compounds 1-11 and 16-18 share the same polyketide origin of the skeleton and belong to aspyrone co-metabolites. All isolates were tested for cytotoxic, anti-food allergic, anti-H1N1 virus, anti-microbe, and anti-inflammatory activities in vitro. Results showed that compounds 5-8 and 13-17 exerted significant cytotoxic effects on BV-2 cell line, and compound 16 showed the potential of anti-inflammatory activities.
从深海来源的曲霉属（Aspergillus）真菌中分离得到了 10 个新的 C 聚酮化合物（asperochratides A-J，1-10）和 14 个已知的杂化合物（11-24）。通过广泛的光谱分析、改进的 Mosher 法、Mo(OAc)诱导圆二色性（ICD）实验和 ECD 计算，确定了新化合物的结构。在结构上，化合物 1-11 和 16-18 具有相同的多酮骨架起源，属于 aspyrone 共代谢物。所有分离物均在体外进行了细胞毒性、抗食物过敏、抗 H1N1 病毒、抗微生物和抗炎活性测试。结果表明，化合物 5-8 和 13-17 对 BV-2 细胞系表现出显著的细胞毒性作用，化合物 16 表现出潜在的抗炎活性。
