Henan Key Laboratory of Polyoxometalates, Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, PR China.
School of Pharmaceutical Sciences, Nanjing Tech University, No.30 South Puzhu Road, Nanjing 211816, PR China.
Int J Pharm. 2020 Dec 15;591:119990. doi: 10.1016/j.ijpharm.2020.119990. Epub 2020 Oct 16.
Herein, a polyoxometalate (POM)-based blend hydrogel system was in situ constructed by incorporating cetyltrimethylammoniumbromide (CTAB)-encapsulated POM cationic micelles to bare hydrogel matrixes followed by copolymerization of multivalent crosslinking groups. It was demonstrated that the fabricated blend hydrogel possessed tunable physicochemical properties, good swelling behavior (maximum swelling rate of 229% in buffer solution of pH 8.0), excellent local action and sustained release of POM component (release ratio achieved nearly 100% at the time of 120 min). Antibacterial activity study revealed that the introduction of POM greatly improved the bioavailability of itself, namely, leading to a more effective enhancement of therapeutic effects (survival ratio of both strains less than 5%). Besides, bactericidal rates (ca. 51%) were achieved even after six runs repeated, thereby verifying the biological application potential of this material. Finally, the practical application potentials were investigated and future prospects in relevant research areas were forecasted.
本文通过将 CTAB 包裹的多酸阳离子胶束掺入裸水凝胶基质中，然后进行多价交联基团的共聚，原位构建了一种基于多酸的混合水凝胶体系。结果表明，所制备的混合水凝胶具有可调节的物理化学性质、良好的溶胀行为（在 pH 值为 8.0 的缓冲溶液中的最大溶胀率为 229%）、优异的局部作用和多酸组分的持续释放（在 120 分钟时释放率达到近 100%）。抗菌活性研究表明，多酸的引入极大地提高了其自身的生物利用度，即导致治疗效果的更有效增强（两种菌株的存活率均小于 5%）。此外，即使重复进行六次运行，也可以达到约 51%的杀菌率，从而验证了该材料的生物应用潜力。最后，考察了实际应用潜力，并预测了相关研究领域的未来前景。
