Department of Inorganic Chemistry Faculty of Science, P.J. Šafárik University, Moyzesova 11, SK-041 54 Košice, Slovakia.
Institute of Physics, P. J. Šafárik University, Park Angelinum 9, 04001 Košice, Slovakia.
Molecules. 2020 Oct 15;25(20):4722. doi: 10.3390/molecules25204722.
In this work we describe the relationship between surface modification of hexagonally ordered mesoporous silica SBA-15 and loading/release characteristics of nonsteroidal anti-inflammatory drug (NSAID) naproxen. Mesoporous silica (MPS) was modified with 3-aminopropyl, phenyl and cyclohexyl groups by grafting method. Naproxen was adsorbed into pores of the prepared MPS from ethanol solution using a solvent evaporation method. The release of the drug was performed in buffer medium at pH 2 and physiological solution at pH 7.4. Parent MPSs as well as naproxen loaded MPSs were characterized using physicochemical techniques such as nitrogen adsorption/desorption, thermogravimetric analysis (TG), Zeta potential analysis, Fourier transform infrared spectroscopy (FT-IR), and elemental analysis. The amount of naproxen released from the MPSs into the medium was determined by high-performance liquid chromatography (HPLC). It was shown that the adsorption and desorption characteristics of naproxen are dependent on the pH of the solution and the surface functionalization of the host.
在这项工作中，我们描述了六方有序介孔硅 SBA-15 的表面修饰与非甾体抗炎药（NSAID）萘普生的负载/释放特性之间的关系。通过接枝法用 3-氨丙基、苯基和环己基对介孔硅（MPS）进行修饰。萘普生通过溶剂蒸发法从乙醇溶液中被吸附到制备的 MPS 的孔中。在 pH 值为 2 的缓冲介质和 pH 值为 7.4 的生理溶液中进行药物释放。使用物理化学技术，如氮气吸附/解吸、热重分析（TG）、Zeta 电位分析、傅里叶变换红外光谱（FT-IR）和元素分析对母体 MPS 以及负载萘普生的 MPS 进行了表征。通过高效液相色谱（HPLC）测定了 MPS 向介质中释放的萘普生的量。结果表明，萘普生的吸附和解吸特性取决于溶液的 pH 值和主体的表面功能化。
