Svatun B, Saxton C A, van der Ouderaa F, Rölla G
Gibbs Dental Division, Unilever Research, Port Sunlight Laboratory, Bebington, Wirral, England.
J Clin Periodontol. 1987 Sep;14(8):457-61. doi: 10.1111/j.1600-051x.1987.tb02251.x.
The purpose of the present investigation was to test the concept that a dentifrice containing zinc citrate and Triclosan could maintain gingival health. The gingival health of 101 young predominately female student nurses in Oslo was brought to a high level by professional cleaning supported by oral hygiene instruction. The criterion of gingival health was less than or equal to 5 elicited bleeding sites from a full mouth assessment. The mean bleeding value attained for the whole group was 3.5. 2 balanced groups were formed, based on the initial number of elicited bleeding sites and plaque values. One group used the test dentifrice and the other group the placebo for 6 months, with an intermediate assessment after 3 months. The placebo group failed to maintain the standard of oral hygiene and gingival health that had been achieved by professional care. In contrast, the group using the test dentifrice for 6 months exhibited similar levels of plaque and gingival health to that observed at baseline following oral hygiene instruction. After 6 months, less than 7% of the subjects in the placebo group possessed healthy gingivae in contrast to 60% of the test group. Thus a dentifrice containing a zinc salt and nonionic germicide had successfully maintained gingival health in a group of young adults.
本研究的目的是验证含有柠檬酸锌和三氯生的牙膏能够维持牙龈健康这一概念。在奥斯陆,101名以年轻女性为主的学生护士通过专业清洁和口腔卫生指导,其牙龈健康状况达到了较高水平。牙龈健康的标准是在全口评估中引发出血的部位小于或等于5处。整个组达到的平均出血值为3.5。根据最初引发出血的部位数量和牙菌斑值,形成了2个平衡组。一组使用测试牙膏,另一组使用安慰剂,为期6个月,3个月后进行中期评估。安慰剂组未能维持专业护理所达到的口腔卫生和牙龈健康标准。相比之下,使用测试牙膏6个月的组在牙菌斑和牙龈健康水平上与口腔卫生指导后的基线观察水平相似。6个月后,安慰剂组中不到7%的受试者牙龈健康,而测试组为60%。因此,一种含有锌盐和非离子杀菌剂的牙膏成功地在一组年轻人中维持了牙龈健康。