Department of Human Neurosciences, Sapienza University of Rome , Rome, Italy.
Sapienza University of Rome , Rome, Italy.
Expert Rev Pharmacoecon Outcomes Res. 2021 Feb;21(1):55-68. doi: 10.1080/14737167.2021.1841638. Epub 2020 Nov 5.
The clinical, social, and economic implications of Parkinson's disease (PD) are significant; disability occurs leading to a low quality of life (QoL). Information on the QoL of patients with PD and studies on the relationship between QoL and motor and cognitive function are necessary for both research and clinical use to make informed decisions in healthcare and rehabilitation. The aim of this study was to determine which scales are most used to assess QoL in patients with PD.
A literature search was conducted in MEDLINE, Scopus, CINAHL, PsycINFO, and Web of Science. Two authors independently identified eligible studies based on predefined inclusion criteria and extracted the data. Study quality and the risk of bias were assessed using the COSMIN checklist.
116 suitable studies were included, and 42 different instruments were identified. The most frequently used scales were the 39-items and 8-items Parkinson's Disease Questionnaire (PDQ-39) (PDQ-8). These findings suggest further investigation of existing PD outcome measures would benefit patients, researchers, and clinicians. Validated, universal outcome measures are required to allow comparisons across practice; therefore, we recommend that future researchers use a common set of outcome assessments based on the results of this review.
帕金森病（PD）在临床、社会和经济方面的影响巨大；其导致残疾，从而降低生活质量（QoL）。了解 PD 患者的 QoL 以及 QoL 与运动和认知功能之间关系的研究对于研究和临床应用都非常必要，这有助于在医疗保健和康复方面做出明智的决策。本研究旨在确定评估 PD 患者 QoL 最常用的量表。
在 MEDLINE、Scopus、CINAHL、PsycINFO 和 Web of Science 中进行了文献检索。两位作者根据预先设定的纳入标准独立识别合格的研究并提取数据。使用 COSMIN 清单评估研究质量和偏倚风险。
纳入了 116 项合适的研究，确定了 42 种不同的工具。最常用的量表是 39 项和 8 项帕金森病问卷（PDQ-39）（PDQ-8）。这些发现表明，对现有 PD 结果测量的进一步研究将使患者、研究人员和临床医生受益。需要有效的、通用的结果测量方法来允许在实践中进行比较；因此，我们建议未来的研究人员根据本综述的结果使用一套通用的结果评估方法。
