Department of Chemistry and Biochemistry, University of Wisconsin-Eau Claire, Eau Claire, USA.
Protein J. 2020 Dec;39(6):644-656. doi: 10.1007/s10930-020-09935-8. Epub 2020 Oct 26.
Novel coronavirus disease 2019 (COVID-19) has resulted in a global pandemic and is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have suggested that a precise disulfide-thiol balance is crucial for viral entry and fusion into the host cell and that oxidative stress generated from free radicals can affect this balance. Here, we reviewed the current knowledge about the role of oxidative stress on SARS-CoV and SARS-CoV-2 infections. We focused on the impact of antioxidants, like NADPH and glutathione, and redox proteins, such as thioredoxin and protein disulfide isomerase, that maintain the disulfide-thiol balance in the cell. The possible influence of these biomolecules on the binding of viral protein with the host cell angiotensin-converting enzyme II receptor protein as well as on the severity of COVID-19 infection was discussed.
新型冠状病毒病 2019（COVID-19）已导致全球大流行，由严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引起。几项研究表明，精确的二硫键-巯基平衡对于病毒进入和融合到宿主细胞至关重要，而自由基产生的氧化应激会影响这种平衡。在这里，我们回顾了关于氧化应激对 SARS-CoV 和 SARS-CoV-2 感染的作用的现有知识。我们重点讨论了抗氧化剂，如 NADPH 和谷胱甘肽，以及氧化还原蛋白，如硫氧还蛋白和蛋白二硫键异构酶，对细胞中二硫键-巯基平衡的影响。讨论了这些生物分子对病毒蛋白与宿主细胞血管紧张素转换酶 II 受体蛋白结合以及 COVID-19 感染严重程度的可能影响。
