Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians-University Munich, Goethestr. 70, 80336, Munich, Germany.
Biomaterials Department, Faculty of Oral and Dental Medicine, Cairo University, Cairo, Egypt.
Clin Oral Investig. 2021 May;25(5):3237-3247. doi: 10.1007/s00784-020-03654-1. Epub 2020 Oct 27.
This study evaluated the adhesion and whitening effects of a combination of P11-4 self-assembling peptide and hydroxyapatite (peptide-HAP) on bovine enamel.
Forty-six caries-free bovine teeth were selected, and 40 teeth were randomly allocated to one of five groups (n = 8). First, the effects of application frequency, exposure time, and storage in saliva on the whitening effects of an experimental low-concentrated peptide-HAP suspension (0.5 wt% HAP; Curodont, Credentis) were evaluated and compared with a commercial bleaching agent (VivaStyle Paint on Plus, VS, Ivoclar Vivadent). Tooth color was measured using a spectrophotometer (Gretag MacBeth), and color changes ΔE were statistically analyzed. Second, the effects of peptide-HAP concentration (low versus high: 6.25% HAP; Curodont Protect), and its interactions with saliva and postapplication restaining, were investigated. Third, enamel surfaces (n = 2) were treated with low concentration peptide-HAP and high-concentration peptide-HAP in polymeric and monomeric forms (Curodont Protect & Curodont Repair, Credentis) and analyzed by SEM.
The ΔE of the low-concentration peptide-HAP suspension did not differ from that of VS. Application frequency, exposure time, and storage in saliva did not have any significant impact on whitening efficacy of the peptide-HAP suspension. Increasing the concentration of the suspension did not promote overall ΔE. SEM observations confirmed the presence of the newly generated peptide and HAP on the enamel surface.
The peptide-HAP suspension is a mild tooth whitener, and the adhesion of peptide-HAP to enamel is concentration dependent.
This peptide-HAP suspension is effective in offsetting discoloration caused by restaining after treatment.
本研究评估了 P11-4 自组装肽与羟基磷灰石（肽-HAP）联合对牛牙釉质的黏附性和美白效果。
选择 46 颗无龋牛牙，将 40 颗牙齿随机分为五组（n = 8）。首先，评估并比较了应用频率、暴露时间和唾液储存对实验性低浓度肽-HAP 悬浮液（0.5wt% HAP；Curodont，Credentis）美白效果的影响，该悬浮液与商业漂白剂（VivaStyle Paint on Plus，VS，Ivoclar Vivadent）进行比较。使用分光光度计（Gretag MacBeth）测量牙齿颜色，统计分析颜色变化ΔE。其次，研究了肽-HAP 浓度（低浓度与高浓度：6.25% HAP；Curodont Protect）及其与唾液的相互作用以及应用后的再染色。第三，用低浓度肽-HAP 和高浓度肽-HAP（Curodont Protect & Curodont Repair，Credentis）的聚合和单体形式处理牙釉质表面（n = 2），并通过 SEM 进行分析。
低浓度肽-HAP 悬浮液的ΔE 与 VS 无差异。应用频率、暴露时间和唾液储存对肽-HAP 悬浮液的美白效果没有任何显著影响。增加悬浮液的浓度不会促进整体ΔE。SEM 观察证实了新生成的肽和 HAP 存在于牙釉质表面。
肽-HAP 悬浮液是一种温和的牙齿美白剂，肽-HAP 对牙釉质的黏附性与浓度有关。
这种肽-HAP 悬浮液可有效抵消治疗后再染色引起的变色。
