糖尿病患者的红细胞参数及其与肾功能检查的相关性：一项比较性横断面研究。
Red Blood Cell Parameters and Their Correlation with Renal Function Tests Among Diabetes Mellitus Patients: A Comparative Cross-Sectional Study.
作者信息
Adane Tiruneh, Getaneh Zegeye, Asrie Fikir
机构信息
School of Biomedical and Laboratory Sciences, Department of Hematology and Immunohematology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
出版信息
Diabetes Metab Syndr Obes. 2020 Oct 23;13:3937-3946. doi: 10.2147/DMSO.S275392. eCollection 2020.
BACKGROUND
Diabetes mellitus (DM) patients show a significant derangement in various hematological parameters including changes affecting the red blood cells (RBCs). All these derangements have an imposing effect on any of the RBC indices. Thus, the main aim of this study was determining the RBCs parameters and their correlation with renal function, and also the magnitude of anemia in DM patients in comparison with healthy controls.
METHODS
A comparative cross-sectional study was conducted at the chronic illness clinic of University of Gondar Hospital from January to April 2020. A total of 246 participants (164 DM and 82 controls) were selected using a simple random sampling technique. Data were collected using a pretested structured questionnaire. Five milliliters venous blood was collected by vacutainer blood collection technique. RBC parameters and renal function tests were determined by using Sysmex KX21N and BS-200E Mindray analyzers, respectively. The data were tested for normality using Shapiro-Wilk and Kolmogorov-Smirnov tests. Independent sample -test and Pearson's and Spearman correlation statistics were used to analyze variables. A p-value ˂0.05 was considered as statistically significant.
RESULTS
The mean hemoglobin (Hgb) concentration was 13.8±0.7 and 15±1.3 among DM and controls, respectively. RBC (p=0.014), Hgb (p ˂0.001), hematocrit (Hct) (p ˂0.001), and mean cell volume (MCV) (p ˂0.001) were significantly lower in DM patients as compared to controls. On the other hand, mean cell hemoglobin concentration (MCHC) was significantly increased in DM patients (p ˂0.001) than the controls. Besides, a significant negative correlation was found between Hgb and creatinine (Cr) in DM patients.
CONCLUSION
The mean values of RBC parameters (RBC, Hgb, Hct, and MCV) for DM patients were found significantly lower than the control groups. Besides a significant negative correlation was found between Cr and RBC indices (RBC, Hgb, Hct, and MCV) in DM patients. It is, therefore, suggested that RBC parameters abnormalities should be evaluated and treated periodically in DM patients for better prognosis and quality of life.
背景
糖尿病（DM）患者的各种血液学参数出现明显紊乱，包括影响红细胞（RBC）的变化。所有这些紊乱对任何红细胞指数都有显著影响。因此，本研究的主要目的是确定糖尿病患者的红细胞参数及其与肾功能的相关性，以及与健康对照组相比糖尿病患者贫血的程度。
方法
2020年1月至4月在贡德尔大学医院慢性病门诊进行了一项比较横断面研究。采用简单随机抽样技术共选取246名参与者（164名糖尿病患者和82名对照组）。使用预先测试的结构化问卷收集数据。采用真空采血管采血技术采集5毫升静脉血。分别使用Sysmex KX21N和迈瑞BS-200E分析仪测定红细胞参数和肾功能。使用Shapiro-Wilk和Kolmogorov-Smirnov检验对数据进行正态性检验。采用独立样本t检验以及Pearson和Spearman相关统计分析变量。p值<0.05被认为具有统计学意义。
结果
糖尿病患者和对照组的平均血红蛋白（Hgb）浓度分别为13.8±0.7和15±1.3。与对照组相比，糖尿病患者的红细胞（RBC）（p=0.014）、血红蛋白（Hgb）（p<0.001）、血细胞比容（Hct）（p<0.001）和平均红细胞体积（MCV）（p<0.001）显著降低。另一方面，糖尿病患者的平均红细胞血红蛋白浓度（MCHC）显著高于对照组（p<0.001）。此外，糖尿病患者的血红蛋白与肌酐（Cr）之间存在显著负相关。
结论
糖尿病患者的红细胞参数（RBC、Hgb、Hct和MCV）平均值显著低于对照组。此外，糖尿病患者的肌酐与红细胞指数（RBC、Hgb、Hct和MCV）之间存在显著负相关。因此，建议对糖尿病患者定期评估和治疗红细胞参数异常，以获得更好的预后和生活质量。
Zotero 插件