埃塞俄比亚南部地区艾滋病病毒感染成年患者血液学参数评估：一项比较性横断面研究。
Evaluation of Hematological Parameters of -Infected Adult Patients at Southern Ethiopia: A Comparative Cross-Sectional Study.
作者信息
Haile Kassahun, Timerga Abebe
机构信息
Department of Medical Laboratory Science, College of Medicine and Health Sciences, Wolkite University, Wolkite, Ethiopia.
Department of Biomedical Science, Wolkite University, Wolkite, Ethiopia.
出版信息
J Blood Med. 2021 Feb 22;12:77-84. doi: 10.2147/JBM.S294958. eCollection 2021.
BACKGROUND
() infection is a global public health problem, a higher burden of the infection was reported in developing countries including Ethiopia. It has been associated with several gastrointestinal diseases, and recently implicated in some hematological abnormalities. Despite the high prevalence of infection in Ethiopia, there was limited data regarding the relationship between hematological parameters with infection. Therefore, this study aimed to evaluate selected hematological parameters of -infected patients attending Wachemo University Nigist Eleni Mohammed Memorial Referral Hospital (WUNEMMRH), Hosanna, Southern, Ethiopia.
METHODS AND MATERIALS
A comparative cross-sectional study was conducted from January to May 2019 among 374 (187 -infected patients and 187controls) study participants. Data on socio-demographic characteristics were collected using a structured questionnaire. A five-milliliter venous blood sample was collected for hematological parameter analysis. Approximately two gram of stool specimen was collected to assess the presence of antigen. Data were entered and analyzed by using SPSS version 21. Pearson correlation analysis and independent sample T-test was performed, and P-value < 0.05 was considered statistically significant.
RESULTS
Mean value of Hgb (p<0.001), RBC count (p<0.001), HCT (p<0.001), MCV (p=0.003), MCH (p=0.008), and MCHC (p=0.006) of -infected patients were significantly lower than control group. However, the mean value of RDW (p=0.003) in -infected patients was significantly higher than in the control group. About 13.3%, 7%, 6.4%, and 18.2% of -infected patients showed reduced Hgb concentration, RBC count, HCT, and MCV values, respectively.
CONCLUSION
The study showed a statistically significant difference in the mean value of Hgb, RBC count, HCT, MCV, MCH, MCHC, and RDW of -infected patients and controls. Thus, hematological parameters should be considered for proper diagnosis and management of -infected patients and eradication of this microorganism from infected patients, determination of hematological parameters for -infected patients were recommended.
背景
（）感染是一个全球性的公共卫生问题，据报道，包括埃塞俄比亚在内的发展中国家感染负担更高。它与多种胃肠道疾病有关，最近还与一些血液学异常有关。尽管埃塞俄比亚感染的患病率很高，但关于血液学参数与感染之间关系的数据有限。因此，本研究旨在评估在埃塞俄比亚南部霍桑纳的瓦切莫大学尼吉斯特·埃莱尼·穆罕默德纪念转诊医院（WUNEMMRH）就诊的感染患者的选定血液学参数。
方法和材料
2019年1月至5月对374名研究参与者（187名感染患者和187名对照）进行了一项比较横断面研究。使用结构化问卷收集社会人口学特征数据。采集5毫升静脉血样进行血液学参数分析。采集约2克粪便标本以评估抗原的存在。数据使用SPSS 21版录入和分析。进行Pearson相关分析和独立样本T检验，P值<0.05被认为具有统计学意义。
结果
感染患者的血红蛋白（Hgb）（p<0.001）、红细胞计数（RBC count）（p<0.001）、血细胞比容（HCT）（p<0.001）、平均红细胞体积（MCV）（p=0.003）、平均红细胞血红蛋白含量（MCH）（p=0.008）和平均红细胞血红蛋白浓度（MCHC）（p=0.006）的平均值显著低于对照组。然而，感染患者的红细胞分布宽度（RDW）（p=0.003）平均值显著高于对照组。分别约13.3%、7%、6.4%和18.2%的感染患者血红蛋白浓度、红细胞计数、血细胞比容和平均红细胞体积值降低。
结论
该研究表明，感染患者和对照组在血红蛋白、红细胞计数、血细胞比容、平均红细胞体积、平均红细胞血红蛋白含量、平均红细胞血红蛋白浓度和红细胞分布宽度的平均值上存在统计学显著差异。因此，为了对感染患者进行正确诊断和管理以及从感染患者中根除这种微生物，建议对感染患者进行血液学参数测定时应考虑血液学参数。
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