Wang Yu, Wang Sinan, Ren Yu, Zhou Xuan
Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, Tianjin, China.
Front Oncol. 2020 Oct 2;10:561833. doi: 10.3389/fonc.2020.561833. eCollection 2020.
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common type of human malignancy. For decades, research into HNSCC invasion and metastasis has been dedicated to the study of protein-coding genes. Along with whole-genome and transcriptome sequencing development, long non-coding RNA (lncRNA) has attracted greater attention. Compelling evidence has proven the critical role of lncRNAs in the occurrence and development of HNSCC by means of epigenetic modifications, regulation of gene transcription, and post-transcription level. More importantly, crosstalk between lncRNAs and microRNAs was recently proven to regulate HNSCC metastasis through EMT modification. Based on these, this review summarizes the critical roles of lncRNAs in HNSCC metastasis and the crosstalk between lncRNAs and microRNAs as well as the detailed regulatory mechanism of the interaction. Thus, a deeper understanding of the lncRNA network in cancer metastasis is finally uncovered in order to provide a rationale and innovative concepts toward new therapeutic strategies for the highly metastatic HNSCC.
头颈部鳞状细胞癌（HNSCC）是人类第六大常见恶性肿瘤类型。几十年来，对头颈部鳞状细胞癌侵袭和转移的研究一直致力于蛋白质编码基因的研究。随着全基因组和转录组测序技术的发展，长链非编码RNA（lncRNA）受到了更多关注。有力证据表明，lncRNA通过表观遗传修饰、基因转录调控和转录后水平在头颈部鳞状细胞癌的发生和发展中起关键作用。更重要的是，最近证实lncRNA与微小RNA之间的相互作用通过上皮-间质转化修饰调节头颈部鳞状细胞癌转移。基于这些，本综述总结了lncRNA在头颈部鳞状细胞癌转移中的关键作用、lncRNA与微小RNA之间的相互作用以及详细的调控机制。因此，最终揭示了对癌症转移中lncRNA网络的更深入理解，以便为高转移性头颈部鳞状细胞癌的新治疗策略提供理论依据和创新概念。
