Department of Medical Imaging, University of Arizona, Tucson, AZ, United States of America.
Department of Biomedical Engineering, University of Arizona, Tuscon, AZ, United States of America.
J Neural Eng. 2020 Oct 30;17(5):056040. doi: 10.1088/1741-2552/abb63a.
This study employs a human head model with real skull to demonstrate the feasibility of transcranial acoustoelectric brain imaging (tABI) as a new modality for electrical mapping of deep dipole sources during treatment of epilepsy with much better resolution and accuracy than conventional mapping methods.
This technique exploits an interaction between a focused ultrasound (US) beam and tissue resistivity to localize current source densities as deep as 63 mm at high spatial resolution (1 to 4 mm) and resolve fast time-varying currents with sub-ms precision.
Detection thresholds through a thick segment of the human skull at biologically safe US intensities was below 0.5 mA and within range of strong currents generated by the human brain.
This work suggests that 4D tABI may emerge as a revolutionary modality for real-time high-resolution mapping of neuronal currents for the purpose of monitoring, staging, and guiding treatment of epilepsy and other brain disorders characterized by abnormal rhythms.
本研究采用具有真实颅骨的人头模型，展示经颅声电脑成像（tABI）作为一种新的模态，用于在治疗癫痫时对深部偶极子源进行电定位，其分辨率和准确性均优于传统的映射方法。
该技术利用聚焦超声（US）束与组织电阻率之间的相互作用，以高空间分辨率（1 至 4 毫米）将深达 63 毫米的电流源密度定位，并以亚毫秒级的精度解析快速时变电流。
在生物安全的超声强度下，通过人体颅骨的厚段的检测阈值低于 0.5 mA，处于人脑产生的强电流范围内。
这项工作表明，4D tABI 可能成为一种革命性的模态，用于实时高分辨率映射神经元电流，以监测、分期和指导癫痫和其他以异常节律为特征的脑疾病的治疗。
