Tennessee Clinical and Translational Science Institute, University of Tennessee Health Science Center, Tennessee, USA.
Columbia University Irving Medical Center, New York, USA.
Clin Nutr. 2021 Apr;40(4):2337-2342. doi: 10.1016/j.clnu.2020.10.024. Epub 2020 Oct 21.
To investigate the longitudinal association between magnesium (Mg) intake and the risk of metabolic syndrome (MetS).
Poisson regression models with robust standard error estimation were used to examine the association between total Mg intake and the risk of MetS in 6802 participants aged ≥45 years at baseline in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Dietary data were collected using the modified Block 98 food frequency questionnaire (FFQ) at baseline and incident MetS was diagnosed during follow-up if a participant had three or more of the five components of MetS based on the harmonized definition.
A total of 1470 participants developed MetS during an average follow-up of 10 years. Comparing the highest quintile of total Mg intake (>437.9 mg/day) to the lowest group (<223.5 mg/day), total Mg intake had a significant inverse association with the risk of MetS [relative risk (RR) = 0.79 (0.63, 0.98), P = 0.043]. Dietary Mg intake was inversely associated with MetS [RR = 0.72 (0.56, 0.91), P = 0.006]. Adjusting for baseline components of MetS attenuated the associations, but the linear trends remained.
The findings from this study indicate that dietary Mg intake was inversely associated with the risk of MetS. We recommend further studies to explain the underlying mechanisms of action.
研究镁（Mg）摄入量与代谢综合征（MetS）风险之间的纵向关联。
采用泊松回归模型和稳健标准误差估计，在基线时年龄≥45 岁的 6802 名 REasons for Geographic And Racial Differences in Stroke（REGARDS）研究参与者中，检查总镁摄入量与 MetS 风险之间的关联。基线时采用改良的 Block 98 食物频率问卷（FFQ）收集饮食数据，在随访期间，如果参与者根据协调定义具有 MetS 的五个成分中的三个或更多，则诊断为新发 MetS。
共有 1470 名参与者在平均 10 年的随访期间发生 MetS。与总镁摄入量最高五分位数（>437.9mg/天）相比，总镁摄入量最低五分位数（<223.5mg/天）与 MetS 风险呈显著负相关[相对风险（RR）=0.79（0.63, 0.98），P=0.043]。饮食镁摄入量与 MetS 呈负相关[RR=0.72（0.56, 0.91），P=0.006]。调整基线 MetS 的组成部分后，关联减弱，但线性趋势仍然存在。
本研究结果表明，饮食镁摄入量与 MetS 风险呈负相关。我们建议进一步研究以解释潜在的作用机制。
