Ju Sang-Yhun, Choi Whan-Seok, Ock Sun-Myeong, Kim Chul-Min, Kim Do-Hoon
Department of Family Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 150-713, Korea.
Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 22 Banpo-daero, Seocho-gu, Seoul 137-701, Korea.
Nutrients. 2014 Dec 22;6(12):6005-19. doi: 10.3390/nu6126005.
ncreasing evidence has suggested an association between dietary magnesium intake and metabolic syndrome. However, previous research examining dietary magnesium intake and metabolic syndrome has produced mixed results. Our objective was to determine the relationship between dietary magnesium intake and metabolic syndrome in the adult population using a dose-response meta-analysis. We searched the PubMed, Embase and the Cochrane Library databases from August, 1965, to May, 2014. Observational studies reporting risk ratios with 95% confidence intervals (CIs) for metabolic syndrome in ≥ 3 categories of dietary magnesium intake levels were selected. The data extraction was performed independently by two authors, and the quality of the studies was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies (RoBANS). Based on eight cross-sectional studies and two prospective cohort studies, the pooled relative risks of metabolic syndrome per 150 mg/day increment in magnesium intake was 0.88 (95% CI, 0.84-0.93; I(2) = 36.3%). The meta-regression model showed a generally linear, inverse relationship between magnesium intake (mg/day) and metabolic syndrome. This dose-response meta-analysis indicates that dietary magnesium intake is significantly and inversely associated with the risk of metabolic syndrome. However, randomized clinical trials will be necessary to address the issue of causality and to determine whether magnesium supplementation is effective for the prevention of metabolic syndrome.
越来越多的证据表明饮食中镁的摄入量与代谢综合征之间存在关联。然而，先前关于饮食中镁的摄入量与代谢综合征的研究结果不一。我们的目标是通过剂量反应荟萃分析确定成年人群中饮食中镁的摄入量与代谢综合征之间的关系。我们检索了1965年8月至2014年5月的PubMed、Embase和Cochrane图书馆数据库。选择了报告≥3类饮食镁摄入量水平下代谢综合征风险比及95%置信区间（CI）的观察性研究。由两位作者独立进行数据提取，并使用非随机研究偏倚风险评估工具（RoBANS）评估研究质量。基于八项横断面研究和两项前瞻性队列研究，镁摄入量每增加150毫克/天，代谢综合征的合并相对风险为0.88（95%CI，0.84 - 0.93；I² = 36.3%）。荟萃回归模型显示镁摄入量（毫克/天）与代谢综合征之间存在大致线性的负相关关系。这项剂量反应荟萃分析表明，饮食中镁的摄入量与代谢综合征风险显著负相关。然而，需要进行随机临床试验来解决因果关系问题，并确定补充镁是否对预防代谢综合征有效。
