Sutrisno Linawati, Hu Yan, Hou Yanhua, Cai Kaiyong, Li Menghuan, Luo Zhong
School of Life Science, Chongqing University, Chongqing, China.
Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, China.
Front Chem. 2020 Sep 10;8:680. doi: 10.3389/fchem.2020.00680. eCollection 2020.
Artificial nanoscale enzyme-mimics (nanozymes) are promising functional alternatives to natural enzymes and have aroused great interest due to their inherent stability, affordability, and high catalytic ability. Iron-based nanozymes are one of the most investigated synthetic nanomaterials with versatile enzyme-like catalytic properties and have demonstrated remarkable relevance to a variety of biomedical applications, especially biocatalytic therapy against tumor indications. Nevertheless, despite the recent advances in biology and nanotechnology, the therapeutic performance of iron-based nanozymes is still limited by technical issues such as low catalytic efficiency and lack of tumor specificity. In this mini review, we briefly summarized the representative studies of iron-based nanozymes, while special emphasis was placed on the current challenges and future direction regarding the therapeutic implementation of iron-based nanozymes for the development of advanced tumor therapies with improved availability and biosafety.
人工纳米级酶模拟物（纳米酶）是天然酶很有前景的功能替代物，因其固有的稳定性、经济性和高催化能力而引起了极大的兴趣。铁基纳米酶是研究最多的具有多种类酶催化特性的合成纳米材料之一，并且已证明与多种生物医学应用显著相关，尤其是针对肿瘤适应症的生物催化治疗。然而，尽管最近在生物学和纳米技术方面取得了进展，但铁基纳米酶的治疗性能仍然受到诸如催化效率低和缺乏肿瘤特异性等技术问题的限制。在这篇小型综述中，我们简要总结了铁基纳米酶的代表性研究，同时特别强调了在开发具有更高可用性和生物安全性的先进肿瘤治疗方法时，铁基纳米酶治疗应用方面当前面临的挑战和未来方向。
