Korajkic Asja, McMinn Brian R, Staley Zachery R, Ahmed Warish, Harwood Valerie J
United Stated Environmental Protection Agency, Cincinnati, OH, USA.
University of Nebraska - Lincoln, Lincoln, NE, USA.
Curr Opin Environ Sci Health. 2020 Aug 1;19:92-100. doi: 10.1016/j.coesh.2020.07.003.
Antibiotic-resistant (ARE) are among leading causes of nosocomial infections worldwide. spp. are ubiquitous in sewage, which can contaminate surface waters via many pathways, providing a route of exposure for humans. This review focuses on ARE in marine and estuarine habitats, including marine animals. Phylogenetic confirmation of the genus and intermediate or full resistance to clinically relevant antibiotics were inclusion criteria. The proportion of resistant isolates varied greatly among antibiotics, for example, 24.2% for ampicillin and 2.4% for vancomycin. The water column contained the highest proportion of ARE observations (18.8%), followed by animal feces and tissues (14.8%), sediment (9.4%), and sand (2.0%). The proportion of multidrug-resistant isolates was the greatest in animal tissue and fecal samples, followed by water and sediments. This review indicates that clinically relevant ARE are present in marine/estuarine habitats and that animals may be important reservoirs.
抗生素耐药菌（ARE）是全球医院感染的主要原因之一。某些菌属在污水中普遍存在，可通过多种途径污染地表水，为人类提供了一条暴露途径。本综述重点关注海洋和河口栖息地中的抗生素耐药菌，包括海洋动物。菌属的系统发育确认以及对临床相关抗生素的中度或完全耐药是纳入标准。耐药分离株的比例在不同抗生素之间差异很大，例如，氨苄西林为24.2%，万古霉素为2.4%。水柱中抗生素耐药菌的观测比例最高（18.8%），其次是动物粪便和组织（14.8%）、沉积物（9.4%）和沙子（2.0%）。多重耐药分离株的比例在动物组织和粪便样本中最高，其次是水和沉积物。本综述表明，临床相关的抗生素耐药菌存在于海洋/河口栖息地，动物可能是重要的储存宿主。
