Material Science Innovation and Modelling (MaSIM) Research Focus Area, Faculty of Natural and Agricultural Sciences, North-West University (Mafikeng Campus), Mmabatho 2735, South Africa.
Department of Chemistry, School of Physical and Chemical Sciences, Faculty of Natural and Agricultural Sciences, North-West University (Mafikeng Campus), Mmabatho 2735, South Africa.
Biosensors (Basel). 2020 Oct 31;10(11):162. doi: 10.3390/bios10110162.
Imbalance in the levels of monoamine neurotransmitters have manifested in severe health issues. Electrochemical sensors have been designed for their determination, with good sensitivity recorded. Carbon-based quantum dots have proven to be an important component of electrochemical sensors due to their high conductivity, low cytotoxicity and opto-electronic properties. The quest for more sensitive electrodes with cheaper materials led to the development of electrochemical sensors based on carbon-based quantum dots for the detection of neurotransmitters. The importance of monoamine neurotransmitters (NTs) and the good electrocatalytic activity of carbon and graphene quantum dots (CQDs and GQDs) make the review of the efforts made in the design of such sensors for monoamine NTs of huge necessity. The differences and the similarities between these two quantum dots are highlighted prior to a discussion of their application in electrochemical sensors over the last ten years. Compared to other monoamine NTs, dopamine (DA) was the most studied with GQDs and CQD-based electrochemical sensors.
单胺神经递质水平失衡已经表现出严重的健康问题。已经设计了电化学传感器来测定它们，记录到了良好的灵敏度。由于具有高导电性、低细胞毒性和光电性能，基于碳的量子点已被证明是电化学传感器的重要组成部分。为了寻找具有更高灵敏度和更廉价材料的电极，人们开发了基于碳量子点的电化学传感器，用于检测神经递质。单胺神经递质 (NTs) 的重要性以及碳和石墨烯量子点 (CQDs 和 GQDs) 的良好电催化活性，使得对设计用于检测单胺 NTs 的此类传感器的努力进行综述变得非常必要。在讨论这两种量子点在过去十年中在电化学传感器中的应用之前，突出了它们之间的差异和相似之处。与其他单胺 NTs 相比，多巴胺 (DA) 是基于 GQDs 和 CQD 的电化学传感器研究最多的。
