Nolan Victoria C, Harrison James, Wright John E E, Cox Jonathan A G
College of Health and Life Sciences, Aston University, Aston Triangle, Birmingham B4 7ET, UK.
Department of Intensive Care Medicine, Great Western Hospital NHS Foundation Trust, Swindon SN3 6BB, UK.
Antibiotics (Basel). 2020 Oct 31;9(11):766. doi: 10.3390/antibiotics9110766.
Antimicrobial resistance is an ever-increasing global issue that has the potential to overtake cancer as the leading cause of death worldwide by 2050. With the passing of the "golden age" of antibiotic discovery, identifying alternative treatments to commonly used antimicrobials is more important than ever. Honey has been used as a topical wound treatment for millennia and more recently has been formulated into a series of medical-grade honeys for use primarily for wound and burn treatment. In this systematic review, we examined the effectiveness of differing honeys as an antimicrobial treatment against a variety of multidrug-resistant (MDR) bacterial species. We analysed 16 original research articles that included a total of 18 different types of honey against 32 different bacterial species, including numerous MDR strains. We identified that Surgihoney was the most effective honey, displaying minimum inhibitory concentrations as low as 0.1% (w/v); however, all honeys reviewed showed a high efficacy against most bacterial species analysed. Importantly, the MDR status of each bacterial strain had no impact on the susceptibility of the organism to honey. Hence, the use of honey as an antimicrobial therapy should be considered as an alternative approach for the treatment of antibiotic-resistant infections.
抗菌耐药性是一个日益严重的全球性问题，到2050年，它有可能超过癌症，成为全球主要死因。随着抗生素发现的“黄金时代”过去，寻找常用抗菌药物的替代疗法比以往任何时候都更加重要。数千年来，蜂蜜一直被用作局部伤口治疗药物，最近还被制成了一系列医用级蜂蜜，主要用于伤口和烧伤治疗。在这项系统评价中，我们研究了不同蜂蜜作为抗微生物治疗对多种耐多药（MDR）细菌的有效性。我们分析了16篇原创研究文章，这些文章共涉及18种不同类型的蜂蜜，针对32种不同细菌，包括许多耐多药菌株。我们发现Surgihoney是最有效的蜂蜜，其最低抑菌浓度低至0.1%（w/v）；然而，所有纳入评价的蜂蜜对大多数分析的细菌种类都显示出高效。重要的是，每个菌株的耐多药状态对该生物体对蜂蜜的敏感性没有影响。因此，蜂蜜作为一种抗菌疗法应被视为治疗抗生素耐药性感染的一种替代方法。
