Bordonne Manon, Chawki Mohammad B, Marie Pierre-Yves, Zaragori Timothée, Roch Véronique, Grignon Rachel, Imbert Laetitia, Verger Antoine
Department of Nuclear Medicine and Nancyclotep Imaging Platform, CHRU-Nancy, Université de Lorraine, F-54000, Nancy, France.
Médecine Nucléaire, CHRU-Nancy Brabois, Allée du Morvan, 54500 Vandoeuvre-lès-, Nancy, France.
EJNMMI Phys. 2020 Nov 4;7(1):65. doi: 10.1186/s40658-020-00334-7.
The aim of this study was to compare brain perfusion SPECT obtained from a 360° CZT and a conventional Anger camera.
The 360° CZT camera utilizing a brain configuration, with 12 detectors surrounding the head, was compared to a 2-head Anger camera for count sensitivity and image quality on 30-min SPECT recordings from a brain phantom and from Tc-HMPAO brain perfusion in 2 groups of 21 patients investigated with the CZT and Anger cameras, respectively. Image reconstruction was adjusted according to image contrast for each camera.
The CZT camera provided more than 2-fold increase in count sensitivity, as compared with the Anger camera, as well as (1) lower sharpness indexes, giving evidence of higher spatial resolution, for both peripheral/central brain structures, with respective median values of 5.2%/3.7% versus 2.4%/1.9% for CZT and Anger camera respectively in patients (p < 0.01), and 8.0%/6.9% versus 6.2%/3.7% on phantom; and (2) higher gray/white matter contrast on peripheral/central structures, with respective ratio median values of 1.56/1.35 versus 1.11/1.20 for CZT and Anger camera respectively in patients (p < 0.05), and 2.57/2.17 versus 1.40/1.12 on phantom; and (3) no change in noise level. Image quality, scored visually by experienced physicians, was also significantly higher on CZT than on the Anger camera (+ 80%, p < 0.01), and all these results were unchanged on the CZT images obtained with only a 15 min recording time.
The 360° CZT camera provides brain perfusion images of much higher quality than a conventional Anger camera, even with high-speed recordings, thus demonstrating the potential for repositioning brain perfusion SPECT to the forefront of brain imaging.
本研究旨在比较使用360° CZT相机和传统安格相机获得的脑灌注单光子发射计算机断层扫描（SPECT）图像。
将采用脑部配置、12个探测器环绕头部的360° CZT相机与双头安格相机进行比较，分别在2组各21例患者中，对来自脑模型的30分钟SPECT记录以及Tc-HMPAO脑灌注情况进行计数灵敏度和图像质量的比较，这2组患者分别使用CZT相机和安格相机进行检查。根据每个相机的图像对比度调整图像重建。
与安格相机相比，CZT相机的计数灵敏度提高了两倍多，并且：（1）锐度指数更低，这表明对于外周/中央脑结构，空间分辨率更高，在患者中，CZT相机和安格相机外周/中央脑结构的锐度指数中位数分别为5.2%/3.7%和2.4%/1.9%（p < 0.01），在模型上分别为8.0%/6.9%和6.2%/3.7%；（2）外周/中央结构上的灰质/白质对比度更高在患者中，CZT相机和安格相机外周/中央结构的灰质/白质对比度比值中位数分别为1.56/1.35和1.11/1.20（p < 0.05），在模型上分别为2.57/2.17和1.40/1.12；（3）噪声水平没有变化。由经验丰富的医生进行视觉评分的图像质量，CZT相机也显著高于安格相机（提高80%，p < 0.01），并且在仅15分钟记录时间获得的CZT图像上，所有这些结果均未改变。
360° CZT相机提供的脑灌注图像质量比传统安格相机高得多，即使在高速记录时也是如此，从而证明了将脑灌注SPECT重新定位到脑成像前沿的潜力。
