Center for Stem Cell Therapeutics and Imaging (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America; Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Center for Stem Cell Therapeutics and Imaging (CSTI), Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States of America.
Biochim Biophys Acta Rev Cancer. 2021 Jan;1875(1):188458. doi: 10.1016/j.bbcan.2020.188458. Epub 2020 Oct 23.
Primary brain tumors are a heterogeneous group of malignancies that originate in cells of the central nervous system. A variety of models tractable for preclinical studies have been developed to recapitulate human brain tumors, allowing us to understand the underlying pathobiology and explore potential treatments. However, many promising therapeutic strategies identified using preclinical models have shown limited efficacy or failed at the clinical trial stage. The inability to develop therapeutic strategies that significantly improve survival rates in patients highlight the compelling need to revisit the design of currently available animal models and explore the use of new models that allow us to bridge the gap between promising preclinical findings and clinical translation. In this review, we discuss current strategies used to model glioblastoma, the most malignant brain tumor in adults and highlight the shortcomings of specific models that must be circumvented for the development of innovative therapeutic strategies.
原发性脑瘤是一组起源于中枢神经系统细胞的异质性恶性肿瘤。已经开发了多种可用于临床前研究的模型来重现人类脑瘤，使我们能够了解潜在的病理生物学并探索潜在的治疗方法。然而，使用临床前模型确定的许多有前途的治疗策略在临床试验阶段显示出有限的疗效或失败。未能开发出显著提高患者生存率的治疗策略，突出表明迫切需要重新审视当前可用动物模型的设计，并探索使用新模型的方法，以便缩小有前途的临床前发现与临床转化之间的差距。在这篇综述中，我们讨论了目前用于模拟胶质母细胞瘤的策略，胶质母细胞瘤是成人中最恶性的脑瘤，并强调了必须克服特定模型的缺点，以便为创新治疗策略的发展提供帮助。
