Tsekoura Maria, Tsepis Elias, Billis Evdokia, Gliatis John
Department of Physiotherapy, School of Health Rehabilitation Sciences, University of Patras, Patras, Greece.
Department of Medicine, School of Health Sciences, University of Patras, Patras, Greece.
Lung India. 2020 Nov-Dec;37(6):479-484. doi: 10.4103/lungindia.lungindia_143_20.
Chronic obstructive pulmonary disease (COPD) is associated with a progressive loss of muscle mass and function and a systemic inflammatory process that can cause sarcopenia.
The objective of this study is to estimate the prevalence rate of sarcopenia in COPD patients and to determine the factors associated with sarcopenic patients living in Western Greece.
European Working Group on Sarcopenia in Older People criteria were applied to 69 outpatients with stable COPD. Body composition, exercise capacity, functional performance, physical activity, and health status were also assessed. COPD disease severity (COPD stage) was evaluated with the Global Initiative for chronic obstructive lung disease. The study protocol was approved by the Ethical Committee of the Technological Educational Institute of Western Greece.
The sample comprised 69 patients (59 women and 10 men), with a mean age of 71.33 ± 7.48 years. The prevalence of sarcopenia was 24.6% (n = 17). A high percentage (82.6%; n = 57) of the 69 Greek participants did not perform any regular exercise. The findings of this study demonstrated that sarcopenia was positively associated with COPD, age, body mass index, skeletal muscle mass, hand grip strength, and 4 m test.
In conclusion, there is a 24.6% prevalence of sarcopenia in patients with COPD. Further research with larger samples would be indicated to clarify the precise association of specific characteristics of patients with sarcopenia and COPD.
慢性阻塞性肺疾病（COPD）与肌肉质量和功能的逐渐丧失以及可导致肌肉减少症的全身炎症过程相关。
本研究的目的是估计COPD患者中肌肉减少症的患病率，并确定希腊西部COPD患者中肌肉减少症的相关因素。
将欧洲老年人肌肉减少症工作组的标准应用于69例稳定期COPD门诊患者。还评估了身体成分、运动能力、功能表现、身体活动和健康状况。采用慢性阻塞性肺疾病全球倡议评估COPD疾病严重程度（COPD分期）。该研究方案经希腊西部技术教育学院伦理委员会批准。
样本包括69例患者（59名女性和10名男性），平均年龄为71.33±7.48岁。肌肉减少症的患病率为24.6%（n = 17）。69名希腊参与者中有很大比例（82.6%；n = 57）未进行任何规律运动。本研究结果表明，肌肉减少症与COPD、年龄、体重指数、骨骼肌质量、握力和4米步行试验呈正相关。
总之，COPD患者中肌肉减少症的患病率为24.6%。需要进行更大样本量的进一步研究，以阐明肌肉减少症患者与COPD患者特定特征之间的确切关联。
