Wu Yu-Hsueh, Chiang Chun-Pin
Department of Stomatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Institute of Oral Medicine, School of Dentistry, National Cheng Kung University, Tainan, Taiwan.
J Dent Sci. 2024 Oct;19(4):1919-1923. doi: 10.1016/j.jds.2024.07.030. Epub 2024 Aug 3.
Many people have associated e-cigarettes with adjectives such as trendy and cool, and regarded vaping as "a safer alternative to cigarette smoking". Compared with the conventional cigarettes, the public is less familiar with the dangers of e-cigarettes. E-cigarettes produce an aerosol by heating the e-liquid (usually comprising nicotine, flavorings, propylene glycol, vegetable glycerin, and other additives). Harmful substances are generated during the vaporization, such as formaldehyde. Cellular damages and DNA hypermethylation are also found to be associated with vaping. We reviewed the clinical neoplastic cases of patients with vaping history (three oral squamous cell carcinomas, one conjunctival squamous intraepithelial neoplasia, and one thoracic NUT-midline carcinoma). These patients tend to be younger than the average cancer patients. Although the exact relations between the cellular damages or DNA hypermethylation and vaping still need further investigations, we should be very careful about the dangers of using e-cigarettes as aids for cigarette smoking cessation.
许多人将电子烟与时尚、酷炫等形容词联系在一起，并将吸电子烟视为“比吸烟更安全的选择”。与传统香烟相比，公众对电子烟的危害了解较少。电子烟通过加热电子液体（通常包含尼古丁、调味剂、丙二醇、蔬菜甘油和其他添加剂）产生气溶胶。汽化过程中会产生有害物质，如甲醛。还发现细胞损伤和DNA高甲基化与吸电子烟有关。我们回顾了有吸电子烟史患者的临床肿瘤病例（3例口腔鳞状细胞癌、1例结膜鳞状上皮内瘤变和1例胸段NUT中线癌）。这些患者往往比普通癌症患者更年轻。尽管细胞损伤或DNA高甲基化与吸电子烟的确切关系仍需进一步研究，但我们应非常谨慎地看待使用电子烟辅助戒烟的危险性。
