壳聚糖修饰的 Ag 和 CoO 纳米粒子的绿色生物合成改良：表面形态、光催化和生物医学应用之间的关系。
Improved green biosynthesis of chitosan decorated Ag- and CoO-nanoparticles: A relationship between surface morphology, photocatalytic and biomedical applications.
机构信息
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
Department of Chemistry, Sharif University of Technology, Tehran, Iran.
出版信息
Nanomedicine. 2021 Feb;32:102331. doi: 10.1016/j.nano.2020.102331. Epub 2020 Nov 10.
AgNPs@Chitosan and CoO-NPs@Chitosan were fabricated with Salvia hispanica. Results showed MZI values of 5 and 30 mm for CoO-NPs- and AgNPs@Chitosan against S. aureus, and 15 and 21 mm for CoO-NPs- and AgNPs@Chitosan against E. coli (24 h, 20 μg/mL), respectively. MTT assays showed up to 80% and 90%, 71% and 75%, and 91% and 94% mammalian cell viability for the green synthesized, chemically synthesized AgNPs and green synthesized AgNPs@Chitosan for HEK-293 and PC12 cells, respectively, and 70% and 71%, 59% and 62%, and 88% and 73% for the related CoO-NPs (24 h, 20 μg/mL). The photocatalytic activities showed dye degradation after 135 and 105 min for AgNPs@Chitosan and CoO-NPs@Chitosan, respectively. FESEM results showed differences in particle sizes (32 ± 3.0 nm for the AgNPs and 41 ± 3.0 nm for the CoONPs) but AFM results showed lower roughness of the AgNPs@Chitosan (7.639 ± 0.85 nm) compared to CoONPs@Chitosan (9.218 ± 0.93 nm), which resulted in potential biomedical applications.
AgNPs@壳聚糖和 CoO-NPs@壳聚糖是用西班牙鼠尾草制备的。结果表明，CoO-NPs 和 AgNPs@壳聚糖对金黄色葡萄球菌的 MZI 值分别为 5mm 和 30mm，对大肠杆菌的 MZI 值分别为 15mm 和 21mm（24h，20μg/mL）。MTT 试验表明，绿色合成的、化学合成的 AgNPs 和绿色合成的 AgNPs@壳聚糖对 HEK-293 和 PC12 细胞的细胞活力分别高达 80%和 90%、71%和 75%、91%和 94%，而相关的 CoO-NPs（24h，20μg/mL）分别为 70%和 71%、59%和 62%、88%和 73%。光催化活性表明，AgNPs@壳聚糖和 CoO-NPs@壳聚糖分别在 135 和 105min 后显示出染料降解。FESEM 结果显示粒径存在差异（AgNPs 为 32±3.0nm，CoONPs 为 41±3.0nm），但 AFM 结果显示 AgNPs@壳聚糖的粗糙度较低（7.639±0.85nm），低于 CoONPs@壳聚糖（9.218±0.93nm），这可能使其在生物医学方面具有应用潜力。
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