解析 mTOR 的核功能的多面性。
Unraveling the multifaceted nature of the nuclear function of mTOR.
机构信息
Department of Biochemistry and Molecular Biology, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America.
Department of Cell Biology and Anatomy, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America.
出版信息
Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118907. doi: 10.1016/j.bbamcr.2020.118907. Epub 2020 Nov 12.
Abstract
Positioned at the axis between the cell and its environment, mTOR directs a wide range of cellular activity in response to nutrients, growth factors, and stress. Our understanding of the role of mTOR is evolving beyond the spatial confines of the cytosol, and its role in the nucleus becoming ever more apparent. In this review, we will address various studies that explore the role of nuclear mTOR (nmTOR) in specific cellular programs and how these pathways influence one another. To understand the emerging roles of nuclear mTOR, we discuss data and propose plausible mechanisms to offer novel ideas, hypotheses, and future research directions.
摘要
mTOR 位于细胞与其环境的轴线上，可根据营养物质、生长因子和应激情况来指挥广泛的细胞活动。我们对 mTOR 作用的理解已超出了细胞质的空间范围，其在核内的作用也变得越来越明显。在这篇综述中，我们将讨论各种研究，以探究核 mTOR（nmTOR）在特定细胞程序中的作用，以及这些途径如何相互影响。为了理解核 mTOR 的新兴作用，我们将讨论数据并提出合理的机制，以提供新的思路、假设和未来的研究方向。
相似文献
1
Unraveling the multifaceted nature of the nuclear function of mTOR.解析 mTOR 的核功能的多面性。
Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118907. doi: 10.1016/j.bbamcr.2020.118907. Epub 2020 Nov 12.
2
Nuclear mTOR Signaling Orchestrates Transcriptional Programs Underlying Cellular Growth and Metabolism.核 mTOR 信号转导调控细胞生长和代谢相关的转录程序。
Cells. 2024 May 3;13(9):781. doi: 10.3390/cells13090781.
3
MITF-MIR211 axis is a novel autophagy amplifier system during cellular stress.MITF-MIR211 轴是细胞应激过程中新型的自噬放大系统。
Autophagy. 2019 Mar;15(3):375-390. doi: 10.1080/15548627.2018.1531197. Epub 2018 Oct 16.
4
Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth.mTOR 的规范信号传导和核活性——调节代谢和细胞生长的团队合作。
FEBS J. 2018 May;285(9):1572-1588. doi: 10.1111/febs.14384. Epub 2018 Jan 31.
5
Beyond control of protein translation: what we have learned about the non-canonical regulation and function of mammalian target of rapamycin (mTOR).超越蛋白质翻译控制：我们对雷帕霉素哺乳动物靶点（mTOR）的非经典调控和功能的了解。
Biochim Biophys Acta. 2013 Jul;1834(7):1434-48. doi: 10.1016/j.bbapap.2012.12.010. Epub 2012 Dec 29.
6
Nuclear mTOR acts as a transcriptional integrator of the androgen signaling pathway in prostate cancer.核 mTOR 作为雄激素信号通路在前列腺癌中的转录整合因子。
Genes Dev. 2017 Jun 15;31(12):1228-1242. doi: 10.1101/gad.299958.117. Epub 2017 Jul 19.
7
mTOR in health and in sickness.健康与疾病状态下的mTOR
J Mol Med (Berl). 2015 Oct;93(10):1061-73. doi: 10.1007/s00109-015-1326-7. Epub 2015 Sep 22.
8
mTOR signaling in disease.mTOR 信号通路与疾病。
Curr Opin Cell Biol. 2011 Dec;23(6):744-55. doi: 10.1016/j.ceb.2011.09.003. Epub 2011 Sep 29.
9
Whey Protein Concentrate Renders MDA-MB-231 Cells Sensitive to Rapamycin by Altering Cellular Redox State and Activating GSK3β/mTOR Signaling.乳清蛋白浓缩物通过改变细胞氧化还原状态和激活 GSK3β/mTOR 信号通路使 MDA-MB-231 细胞对雷帕霉素敏感。
Sci Rep. 2017 Nov 21;7(1):15976. doi: 10.1038/s41598-017-14159-5.
10
mTOR Signaling in Growth, Metabolism, and Disease.生长、代谢及疾病中的mTOR信号传导
Cell. 2017 Mar 9;168(6):960-976. doi: 10.1016/j.cell.2017.02.004.
引用本文的文献
1
mTOR Modulates NLRP3 Inflammasome Activation via Nuclear Translocation and STAT1 Inhibition.mTOR通过核转位和STAT1抑制调节NLRP3炎性小体激活。
Eur J Immunol. 2025 Jun;55(6):e51176. doi: 10.1002/eji.202451176.
2
The Bi-steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis.双位抑制剂RMC-5552可降低淋巴管平滑肌瘤病中的mTORC1信号传导及生长。
Am J Respir Cell Mol Biol. 2025 Jun;72(6):643-652. doi: 10.1165/rcmb.2024-0242OC.
3
Nuclear mTOR Signaling Orchestrates Transcriptional Programs Underlying Cellular Growth and Metabolism.核 mTOR 信号转导调控细胞生长和代谢相关的转录程序。
Cells. 2024 May 3;13(9):781. doi: 10.3390/cells13090781.
4
MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors.mTOR调节会诱导组蛋白甲基化发生选择性扰动，从而影响mTOR抑制剂的抗增殖作用。
iScience. 2024 Feb 12;27(3):109188. doi: 10.1016/j.isci.2024.109188. eCollection 2024 Mar 15.
5
Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales.荧光生物传感器照亮了细胞信号在不同尺度上的空间调控。
Biochem J. 2023 Oct 31;480(20):1693-1717. doi: 10.1042/BCJ20220223.
6
Regulation of mRNA translation by estrogen receptor in breast cancer.雌激素受体在乳腺癌中对 mRNA 翻译的调控。
Steroids. 2023 Dec;200:109316. doi: 10.1016/j.steroids.2023.109316. Epub 2023 Oct 6.
7
Association of Membranous WNT-1 and Nuclear mTOR with Endometrial Cancer Grade.膜 WNT-1 和核 mTOR 与子宫内膜癌分级的关系。
Int J Mol Sci. 2023 May 6;24(9):8342. doi: 10.3390/ijms24098342.
8
Low temperature and mTOR inhibition favor stem cell maintenance in human keratinocyte cultures.低温和 mTOR 抑制有利于人角质形成细胞培养中的干细胞维持。
EMBO Rep. 2023 Jun 5;24(6):e55439. doi: 10.15252/embr.202255439. Epub 2023 May 4.
9
The Role of Cow's Milk Consumption in Breast Cancer Initiation and Progression.牛奶消费在乳腺癌发生和发展中的作用。
Curr Nutr Rep. 2023 Mar;12(1):122-140. doi: 10.1007/s13668-023-00457-0. Epub 2023 Feb 2.
10
Increased Phospho-AKT in Blood Cells from LRRK2 G2019S Mutation Carriers.血液细胞中 LRRK2 G2019S 突变携带者磷酸化 AKT 增加。
Ann Neurol. 2022 Nov;92(5):888-894. doi: 10.1002/ana.26469. Epub 2022 Sep 26.
本文引用的文献
1
Unconventional Estrogen Signaling in Health and Disease.非传统雌激素信号在健康和疾病中的作用。
Endocrinology. 2020 Apr 1;161(4). doi: 10.1210/endocr/bqaa030.
2
mTOR at the nexus of nutrition, growth, ageing and disease.mTOR 在营养、生长、衰老和疾病的交汇点。
Nat Rev Mol Cell Biol. 2020 Apr;21(4):183-203. doi: 10.1038/s41580-019-0199-y. Epub 2020 Jan 14.
3
mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer.mTORC1作为线粒体功能的调节因子及癌症治疗靶点
Front Oncol. 2019 Dec 13;9:1373. doi: 10.3389/fonc.2019.01373. eCollection 2019.
4
Phosphoproteome Analysis Reveals Estrogen-ER Pathway as a Modulator of mTOR Activity Via DEPTOR.磷酸化蛋白质组分析揭示雌激素-ER 途径通过 DEPTOR 调节 mTOR 活性。
Mol Cell Proteomics. 2019 Aug;18(8):1607-1618. doi: 10.1074/mcp.RA119.001506. Epub 2019 Jun 12.
5
Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f).雌激素受体 α 通过精细调节真核翻译起始因子 3 亚基 f（eIF3f）的表达来促进蛋白质合成。
J Biol Chem. 2019 Feb 15;294(7):2267-2278. doi: 10.1074/jbc.RA118.004383. Epub 2018 Dec 20.
6
SREBF1 Activity Is Regulated by an AR/mTOR Nuclear Axis in Prostate Cancer.SREBF1 活性受前列腺癌中 AR/mTOR 核轴的调节。
Mol Cancer Res. 2018 Sep;16(9):1396-1405. doi: 10.1158/1541-7786.MCR-17-0410. Epub 2018 May 21.
7
Estrogen receptor alpha drives mTORC1 inhibitor-induced feedback activation of PI3K/AKT in ER+ breast cancer.雌激素受体α驱动mTORC1抑制剂诱导的ER+乳腺癌中PI3K/AKT的反馈激活。
Oncotarget. 2018 Jan 15;9(10):8810-8822. doi: 10.18632/oncotarget.24256. eCollection 2018 Feb 6.
8
Canonical signaling and nuclear activity of mTOR-a teamwork effort to regulate metabolism and cell growth.mTOR 的规范信号传导和核活性——调节代谢和细胞生长的团队合作。
FEBS J. 2018 May;285(9):1572-1588. doi: 10.1111/febs.14384. Epub 2018 Jan 31.
9
Landscape of nuclear transport receptor cargo specificity.核转运受体货物特异性全景图。
Mol Syst Biol. 2017 Dec 18;13(12):962. doi: 10.15252/msb.20177608.
10
Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40.RHEB 激活 mTORC1 的机制和 PRAS40 对其的抑制作用。
Nature. 2017 Dec 21;552(7685):368-373. doi: 10.1038/nature25023. Epub 2017 Dec 13.
Zotero 插件