Department of Biochemistry and Molecular Biology, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America.
Department of Cell Biology and Anatomy, Graduate School of Basic Medical Sciences, New York Medical College, Valhalla, NY 10595, United States of America.
Biochim Biophys Acta Mol Cell Res. 2021 Feb;1868(2):118907. doi: 10.1016/j.bbamcr.2020.118907. Epub 2020 Nov 12.
Positioned at the axis between the cell and its environment, mTOR directs a wide range of cellular activity in response to nutrients, growth factors, and stress. Our understanding of the role of mTOR is evolving beyond the spatial confines of the cytosol, and its role in the nucleus becoming ever more apparent. In this review, we will address various studies that explore the role of nuclear mTOR (nmTOR) in specific cellular programs and how these pathways influence one another. To understand the emerging roles of nuclear mTOR, we discuss data and propose plausible mechanisms to offer novel ideas, hypotheses, and future research directions.
mTOR 位于细胞与其环境的轴线上，可根据营养物质、生长因子和应激情况来指挥广泛的细胞活动。我们对 mTOR 作用的理解已超出了细胞质的空间范围，其在核内的作用也变得越来越明显。在这篇综述中，我们将讨论各种研究，以探究核 mTOR（nmTOR）在特定细胞程序中的作用，以及这些途径如何相互影响。为了理解核 mTOR 的新兴作用，我们将讨论数据并提出合理的机制，以提供新的思路、假设和未来的研究方向。
