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马科动物从业者对非甾体类关节内治疗药物临床应用的调查。

A Survey of Clinical Usage of Non-steroidal Intra-Articular Therapeutics by Equine Practitioners.

作者信息

Velloso Alvarez Ana, Boone Lindsey H, Braim Amy Poulin, Taintor Jenifer S, Caldwell Fred, Wright James C, Wooldridge Anne A

机构信息

Department of Clinical Sciences, Auburn University, Auburn, AL, United States.

Zoetis, Parsippany, NJ, United States.

出版信息

Front Vet Sci. 2020 Oct 22;7:579967. doi: 10.3389/fvets.2020.579967. eCollection 2020.

Abstract

There are several non-steroidal intra-articular therapeutics (NSIATs) available for use by equine practitioners for the treatment of performance-limiting joint-related pathology. Information is limited on perceived clinical efficacy, recommended treatment protocols, and associated complications. Our objective with this cross-sectional survey was to investigate the current clinical usage of NSIATs by equine practitioners. An electronic cross-sectional convenience survey inquiring about the use of steroidal and NSIATS (platelet-rich plasma, autologous conditioned serum, autologous protein solution, cellular therapies, and polyacrylamide hydrogel) was distributed internationally to equine practitioners. A total of 353 surveys were completed. NSIATs were used by 87.5% of the participants. Corticosteroids and hyaluronic acid remain the intra-articular therapeutic of choice among practitioners, followed by autologous conditioned serum, platelet-rich plasma and autologous conditioned protein. Polyacrylamide hydrogel was the least used. Practitioners were more likely to use NSIATs if their caseload was > 50% equine ( < 0.001), they treated more than 10 horses intra-articularly per month ( < 0.001), and horses treated were considered English sport horses ( = 0.02). Years in practice and practice location did not influence the use of NSIATs. One of the most common reasons why NSIATs were chosen was to treat acute articular pathologies. As survey limitations, answers to questions regarding clinical response and complication rates were based on subjective estimation and practitioners recall, not clinical records. In conclusion, corticosteroids remain the most widely used intra-articular therapeutic. Among the NSIATs, blood-based products are more commonly used by practitioners, followed by cellular and synthetic products. Equine practitioners frequently use NSIATs, choosing to treat acute joint pathology more than previously reported.

摘要

有几种非甾体类关节内治疗药物(NSIATs)可供马医用于治疗限制运动能力的关节相关病变。关于其临床疗效、推荐治疗方案及相关并发症的信息有限。我们进行这项横断面调查的目的是研究马医目前对NSIATs的临床使用情况。一项关于甾体类药物和NSIATs(富血小板血浆、自体条件血清、自体蛋白溶液、细胞疗法和聚丙烯酰胺水凝胶)使用情况的电子横断面便利调查在国际范围内分发给马医。共完成了353份调查问卷。87.5%的参与者使用了NSIATs。皮质类固醇和透明质酸仍是从业者选择的关节内治疗药物,其次是自体条件血清、富血小板血浆和自体条件蛋白。聚丙烯酰胺水凝胶使用最少。如果从业者的病例量>50%为马病例(<0.001)、每月关节内治疗超过10匹马(<0.001)且所治疗的马被认为是英国运动马(=0.02),则他们更有可能使用NSIATs。从业年限和执业地点不影响NSIATs的使用。选择NSIATs最常见的原因之一是治疗急性关节病变。作为调查的局限性,关于临床反应和并发症发生率问题的答案基于主观估计和从业者的回忆,而非临床记录。总之,皮质类固醇仍然是使用最广泛的关节内治疗药物。在NSIATs中,从业者更常使用基于血液的产品,其次是细胞和合成产品。马医经常使用NSIATs,选择治疗急性关节病变的情况比之前报道的更多。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9323/7642446/a7b7f9b73282/fvets-07-579967-g0001.jpg

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