Department of midwifery, nursing and midwifery Faculty, Tabriz University of Medical sciences, Tabriz, Iran.
Social Determinants of Health Research Center, Midwifery Department, Tabriz University of Medical Sciences, Tabriz, Iran.
Complement Ther Med. 2021 Jan;56:102533. doi: 10.1016/j.ctim.2020.102533. Epub 2020 Oct 23.
Increased accumulation of reactive oxygen species (ROS) in the process of oogenesis is one of the most well known causes of ovarian insufficiency and decreased ovarian reserve. Selenium and vitamin E as cofactors of glutathione peroxidase plays an important role in the removal of ROS in the ovary. We evaluated the effects of selenium and vitamin E supplementation on anti-Mullerian hormone (AMH) index and antral follicle count (AFC) (primary outcomes) and mean ovarian volume (MOV) and side effects of these supplements (secondary outcome) in infertile women with occult premature ovarian insufficiency (OPOI).
70 patients were allocated into the control and treatment groups through block randomization method. 35 women in the treatment group received 200 ng selenium and 400IU vitamin E and 35 women in the control group received placebo for a total of 90 days. AMH index, AFC and mean ovarian volume (MOV) were investigated in both groups after 12 months of study.
There was no significant difference between groups before intervention in AMH (Mean difference: -0.08; 95% CI: -0.20 to.08; p=0.33), AFC (-0.71; 95%CI: -1.44 to -0.01; p=0.05) and MOV (-0.55; 95% CI: -0.85 to -0.24; p=0.001). There was a significant increase in AMH (mean difference: 0.59; 95% CI: 0.48 to 0.71; p<0.001), AFC (5.08; 95% CI: 4.36 to 5.08; p<0.001) and MOV (2.17; 95% CI: 1.87 to 2.47; p<0.001) in selenium + vitamin E group compared to placebo group 12 months after intervention. These supplements had no side effects.
Supplementation with selenium and vitamin E can increase AMH, AFC and MOV in women with OPOI.
在卵子发生过程中，活性氧（ROS）的积累增加是卵巢功能不全和卵巢储备减少的最常见原因之一。硒和维生素 E 作为谷胱甘肽过氧化物酶的辅助因子，在卵巢中清除 ROS 中发挥重要作用。我们评估了硒和维生素 E 补充剂对隐匿性卵巢早衰（OPOI）不孕妇女抗苗勒管激素（AMH）指数和窦卵泡计数（AFC）（主要结局）以及平均卵巢体积（MOV）和这些补充剂的副作用（次要结局）的影响。
采用区组随机分组方法将 70 例患者分为对照组和治疗组。治疗组 35 例患者接受 200ng 硒和 400IU 维生素 E，对照组 35 例患者接受安慰剂，共 90 天。研究 12 个月后，比较两组 AMH 指数、AFC 和平均卵巢体积（MOV）。
干预前两组间 AMH（平均差异：-0.08；95%CI：-0.20 至 0.08；p=0.33）、AFC（-0.71；95%CI：-1.44 至-0.01；p=0.05）和 MOV（-0.55；95%CI：-0.85 至-0.24；p=0.001）差异均无统计学意义。治疗组 AMH（平均差异：0.59；95%CI：0.48 至 0.71；p<0.001）、AFC（5.08；95%CI：4.36 至 5.08；p<0.001）和 MOV（2.17；95%CI：1.87 至 2.47；p<0.001）较安慰剂组干预后 12 个月均显著增加，且无副作用。
补充硒和维生素 E 可增加隐匿性卵巢早衰患者的 AMH、AFC 和 MOV。
