Nephrology and Transplantation, Department of Internal Medicine, Erasmus University Medical Center, Erasmus Medical Center, Rotterdam, The Netherlands.
Transplantation Research and Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Transpl Int. 2021 Feb;34(2):233-244. doi: 10.1111/tri.13789. Epub 2021 Jan 15.
Cellular therapy is a promising tool for improving the outcome of organ transplantation. Various cell types with different immunoregulatory and regenerative properties may find application for specific transplant rejection or injury-related indications. The current era is crucial for the development of cellular therapies. Preclinical models have demonstrated the feasibility of efficacious cell therapy in transplantation, early clinical trials have shown safety of several of these therapies, and the first steps towards efficacy studies in humans have been made. In this review, we address the current state of the art of cellular therapies in clinical transplantation and discuss monitoring tools and endpoints for these studies.
细胞疗法是改善器官移植结果的有前途的手段。具有不同免疫调节和再生特性的各种细胞类型可能适用于特定的移植排斥或损伤相关的适应证。当前是细胞疗法发展的关键时期。临床前模型证明了细胞疗法在移植中具有有效性，早期临床试验表明了其中几种疗法的安全性，并且已经迈出了在人体中进行疗效研究的第一步。在这篇综述中，我们讨论了细胞疗法在临床移植中的最新进展，并讨论了这些研究的监测工具和终点。
