Postgraduate Program of Pharmaceutical Innovation, Laboratory of Pharmacognosy and Phytochemistry, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil.
Postgraduate Program in Health Sciences, Federal University of Amapá, Highway Juscelino Kubitschek, Km 02, Macapá 68903-197, Brazil.
Molecules. 2020 Nov 16;25(22):5333. doi: 10.3390/molecules25225333.
The aim of this work was to prepare a nanoemulsion containing the essential oil of resin and to evaluate the larvicidal activity and the residual larvicidal effect against The essential oil was identified by gas chromatography coupled to a mass spectrometer, and the nanoemulsions were prepared using a low-energy method and characterized by photon correlation spectroscopy. The results indicated the major constituents as -cimene (27.70%) and α-Pinene (22.31%). Nanoemulsions had kinetic stability and a monomodal distribution in a hydrophilic-lipophilic balance of 14 with particle diameters of 115.56 ± 1.68 nn and zeta potential of -29.63 ± 3.46 mV. The nanoemulsion showed larvicidal action with LC = 2.91 µg∙mL and residual larvicidal effect for 72 h after application to larvae. Consequently, the nanobiotechnological product derived from the essential oil of resin could be used against infectious disease vectors.
本工作旨在制备含有树脂精油的纳米乳剂，并评价其对 的杀幼虫活性和残留杀幼虫效果。精油通过气相色谱-质谱联用进行鉴定，纳米乳剂采用低能量法制备，并通过光子相关光谱法进行表征。结果表明，主要成分为 - 桧烯（27.70%）和 α-蒎烯（22.31%）。纳米乳剂具有动力学稳定性，亲水亲油平衡值为 14 时呈单模态分布，粒径为 115.56±1.68nm，zeta 电位为-29.63±3.46mV。纳米乳剂对 幼虫表现出杀幼虫作用，LC = 2.91µg·mL，施用于 幼虫后 72 小时仍具有残留杀幼虫效果。因此，源自树脂精油的纳米生物技术产品可用于防治传染病媒介。
