当前对纳米颗粒蛋白质冠层组成的理解综述。
A review of the current understanding of nanoparticles protein corona composition.
作者信息
Breznica Pranvera, Koliqi Rozafa, Daka Arlinda
机构信息
Department of Pharmaceutical Chemistry, Pharmacy Division, Faculty of Medicine, "Hasan Prishtina" University, Prishtina, Republic of Kosovo.
Department of Clinical Pharmacy and Biopharmacy, Pharmacy Division, Faculty of Medicine, "Hasan Prishtina" University, Prishtina, Republic of Kosovo.
出版信息
Med Pharm Rep. 2020 Oct;93(4):342-350. doi: 10.15386/mpr-1756. Epub 2020 Oct 25.
Abstract
Upon entering into the biological environments, the surface of the nanoparticles is immediately coated with proteins and form the so-called a protein corona due to which a nanoparticle changes its "synthetic" identity to a new "biological" identity. Different types of nanoparticles have different protein binding profiles, which is why they have different protein corona composition and therefore it cannot be said that there is a universal protein corona. The composition and amount of protein in the corona depends on the physical and chemical characteristics of the nanoparticles, the type of biological medium and the exposure time. Protein corona increases the diameter but also changes the composition of the surface of the nanoparticles and these changes affect biodistribution, efficacy, and toxicity of the nanoparticles.
摘要
进入生物环境后，纳米颗粒的表面会立即被蛋白质包裹，形成所谓的蛋白质冠层，由于这一过程，纳米颗粒将其“合成”身份转变为新的“生物”身份。不同类型的纳米颗粒具有不同的蛋白质结合模式，这就是它们具有不同蛋白质冠层组成的原因，因此不能说存在通用的蛋白质冠层。冠层中蛋白质的组成和数量取决于纳米颗粒的物理和化学特性、生物介质的类型以及暴露时间。蛋白质冠层不仅会增加纳米颗粒的直径，还会改变其表面组成，而这些变化会影响纳米颗粒的生物分布、功效和毒性。
相似文献
1
A review of the current understanding of nanoparticles protein corona composition.当前对纳米颗粒蛋白质冠层组成的理解综述。
Med Pharm Rep. 2020 Oct;93(4):342-350. doi: 10.15386/mpr-1756. Epub 2020 Oct 25.
2
Effect of nanoparticle size and PEGylation on the protein corona of PLGA nanoparticles.纳米颗粒尺寸和聚乙二醇化对 PLGA 纳米颗粒蛋白质冠的影响。
Eur J Pharm Biopharm. 2019 Aug;141:70-80. doi: 10.1016/j.ejpb.2019.05.006. Epub 2019 May 10.
3
Serum type and concentration both affect the protein-corona composition of PLGA nanoparticles.血清类型和浓度都会影响聚乳酸-羟基乙酸共聚物纳米颗粒的蛋白质冠层组成。
Beilstein J Nanotechnol. 2019 May 6;10:1002-1015. doi: 10.3762/bjnano.10.101. eCollection 2019.
4
Nanoparticle-Protein Interaction: The Significance and Role of Protein Corona.纳米颗粒-蛋白质相互作用：蛋白质冠的意义和作用。
Adv Exp Med Biol. 2018;1048:175-198. doi: 10.1007/978-3-319-72041-8_11.
5
Understanding the nanoparticle-protein corona complexes using computational and experimental methods.运用计算和实验方法理解纳米颗粒-蛋白质冠冕复合物。
Int J Biochem Cell Biol. 2016 Jun;75:162-74. doi: 10.1016/j.biocel.2016.02.008. Epub 2016 Feb 9.
6
Intentional formation of a protein corona on nanoparticles: Serum concentration affects protein corona mass, surface charge, and nanoparticle-cell interaction.纳米颗粒上蛋白质冠的有意形成：血清浓度影响蛋白质冠的质量、表面电荷以及纳米颗粒与细胞的相互作用。
Int J Biochem Cell Biol. 2016 Jun;75:196-202. doi: 10.1016/j.biocel.2015.11.005. Epub 2015 Nov 10.
7
Visualization of the protein corona: towards a biomolecular understanding of nanoparticle-cell-interactions.蛋白质冠的可视化：迈向对纳米颗粒-细胞相互作用的生物分子理解。
Nanoscale. 2017 Jun 29;9(25):8858-8870. doi: 10.1039/c7nr02977b.
8
The impact of protein corona on the behavior and targeting capability of nanoparticle-based delivery system.蛋白质冠对基于纳米颗粒的递药系统的行为和靶向能力的影响。
Int J Pharm. 2018 Dec 1;552(1-2):328-339. doi: 10.1016/j.ijpharm.2018.10.011. Epub 2018 Oct 9.
9
The role of apolipoprotein- and vitronectin-enriched protein corona on lipid nanoparticles for in vivo targeted delivery and transfection of oligonucleotides in murine tumor models.载脂蛋白和富含 vitronectin 的蛋白冠在脂质纳米颗粒中的作用，用于体内靶向递送达寡核苷酸并在小鼠肿瘤模型中进行转染。
Nanoscale. 2019 Oct 28;11(40):18806-18824. doi: 10.1039/c9nr05788a. Epub 2019 Oct 9.
10
Formation of the Protein Corona: The Interface between Nanoparticles and the Immune System.蛋白质冠的形成：纳米颗粒与免疫系统的界面。
Semin Immunol. 2017 Dec;34:52-60. doi: 10.1016/j.smim.2017.10.001. Epub 2017 Oct 21.
引用本文的文献
1
Inorganic Silica Nanoparticles Increase Lysosomal Biology and Protease Activity.无机二氧化硅纳米颗粒可增强溶酶体生物学功能和蛋白酶活性。
Int J Mol Sci. 2025 Aug 26;26(17):8291. doi: 10.3390/ijms26178291.
2
Enhancing Photothermal Therapy Against Breast Cancer Cells by Modulating the End Point of Gold Shell-Isolated Nanoparticles Using Nanostraw-Assisted Injection.通过纳米吸管辅助注射调节金壳隔离纳米颗粒的终点来增强对乳腺癌细胞的光热疗法
ACS Appl Mater Interfaces. 2025 May 14;17(19):27816-27828. doi: 10.1021/acsami.5c00084. Epub 2025 Apr 29.
3
Development of Biocompatible, UV and NIR Excitable Nanoparticles with Multiwavelength Emission and Enhanced Colloidal Stability.具有多波长发射和增强胶体稳定性的生物相容性、紫外线和近红外激发纳米颗粒的开发。
ACS Mater Au. 2025 Jan 1;5(2):353-364. doi: 10.1021/acsmaterialsau.4c00151. eCollection 2025 Mar 12.
4
High-Curvature Features on Branched Nanoconstructs Circumvent Protein Corona Interference.分支纳米结构上的高曲率特征可规避蛋白质冠层干扰。
ACS Appl Mater Interfaces. 2025 Mar 12;17(10):15187-15195. doi: 10.1021/acsami.5c00725. Epub 2025 Feb 27.
5
Selective Adsorption of Thiol-Containing Molecules on Copper Sulfide Surfaces via Molecule-Surface Disulfide Bridges.通过分子-表面二硫键实现含硫醇分子在硫化铜表面的选择性吸附。
J Phys Chem C Nanomater Interfaces. 2025 Jan 17;129(4):1976-1987. doi: 10.1021/acs.jpcc.4c06463. eCollection 2025 Jan 30.
6
AI-Based Prediction of Protein Corona Composition on DNA Nanostructures.基于人工智能预测DNA纳米结构上的蛋白质冠组成
ACS Nano. 2025 Feb 4;19(4):4333-4345. doi: 10.1021/acsnano.4c12259. Epub 2025 Jan 8.
7
Recent Updates on Diverse Nanoparticles and Nanostructures in Therapeutic and Diagnostic Applications with Special Focus on Smart Protein Nanoparticles: A Review.治疗与诊断应用中多种纳米颗粒和纳米结构的最新进展，特别关注智能蛋白质纳米颗粒：综述
ACS Omega. 2024 Oct 10;9(42):42613-42629. doi: 10.1021/acsomega.4c05037. eCollection 2024 Oct 22.
8
AI-based Prediction of Protein Corona Composition on DNA Nanostructures.基于人工智能预测DNA纳米结构上的蛋白质冠层组成。
bioRxiv. 2024 Aug 26:2024.08.25.609594. doi: 10.1101/2024.08.25.609594.
9
Harnessing barley grains for green synthesis of gold and silver nanoparticles with antibacterial potential.利用大麦籽粒进行具有抗菌潜力的金和银纳米粒子的绿色合成。
Discov Nano. 2024 Jun 11;19(1):101. doi: 10.1186/s11671-024-04042-4.
10
A Review for Uncovering the "Protein-Nanoparticle Alliance": Implications of the Protein Corona for Biomedical Applications.揭示“蛋白质 - 纳米颗粒联盟”的综述：蛋白质冠层对生物医学应用的影响
Nanomaterials (Basel). 2024 May 8;14(10):823. doi: 10.3390/nano14100823.
本文引用的文献
1
Protein Corona-Enabled Systemic Delivery and Targeting of Nanoparticles.蛋白冠介导的纳米颗粒系统递送和靶向。
AAPS J. 2020 Jun 3;22(4):83. doi: 10.1208/s12248-020-00464-x.
2
Recent Advances in Understanding the Protein Corona of Nanoparticles and in the Formulation of "Stealthy" Nanomaterials.纳米颗粒蛋白质冠层理解及“隐形”纳米材料制备的最新进展
Front Bioeng Biotechnol. 2020 Apr 3;8:166. doi: 10.3389/fbioe.2020.00166. eCollection 2020.
3
Regulating Protein Corona Formation and Dynamic Protein Exchange by Controlling Nanoparticle Hydrophobicity.通过控制纳米颗粒疏水性来调节蛋白质冠层的形成和蛋白质动态交换
Front Bioeng Biotechnol. 2020 Mar 20;8:210. doi: 10.3389/fbioe.2020.00210. eCollection 2020.
4
Health Impact of Silver Nanoparticles: A Review of the Biodistribution and Toxicity Following Various Routes of Exposure.银纳米颗粒的健康影响：各种暴露途径下的生物分布和毒性综述。
Int J Mol Sci. 2020 Mar 30;21(7):2375. doi: 10.3390/ijms21072375.
5
Unveiling the pitfalls of the protein corona of polymeric drug nanocarriers.揭示聚合物药物纳米载体蛋白冠的陷阱。
Drug Deliv Transl Res. 2020 Jun;10(3):730-750. doi: 10.1007/s13346-020-00745-0.
6
Understanding the Lipid and Protein Corona Formation on Different Sized Polymeric Nanoparticles.了解不同粒径的聚合物纳米颗粒上的脂质和蛋白质冠的形成。
Sci Rep. 2020 Jan 24;10(1):1129. doi: 10.1038/s41598-020-57943-6.
7
Formation of Protein Corona on Nanoparticle Affects Different Complement Activation Pathways Mediated by C1q.纳米颗粒表面蛋白冠的形成会影响 C1q 介导的不同补体激活途径。
Pharm Res. 2019 Dec 23;37(1):10. doi: 10.1007/s11095-019-2747-8.
8
Advances in nanoparticle development for improved therapeutics delivery: nanoscale topographical aspect.用于改善治疗药物递送的纳米颗粒开发进展：纳米级形貌方面
J Tissue Eng. 2019 Sep 17;10:2041731419877528. doi: 10.1177/2041731419877528. eCollection 2019 Jan-Dec.
9
Interactions of Nanoparticles and Biosystems: Microenvironment of Nanoparticles and Biomolecules in Nanomedicine.纳米颗粒与生物系统的相互作用：纳米医学中纳米颗粒与生物分子的微环境
Nanomaterials (Basel). 2019 Sep 24;9(10):1365. doi: 10.3390/nano9101365.
10
Protein Adsorption: A Feasible Method for Nanoparticle Functionalization?蛋白质吸附：一种可行的纳米颗粒功能化方法？
Materials (Basel). 2019 Jun 21;12(12):1991. doi: 10.3390/ma12121991.
Zotero 插件