Department of Physical Therapy and Athletic Training, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA.
Int J Environ Res Public Health. 2020 Nov 21;17(22):8650. doi: 10.3390/ijerph17228650.
Impaired muscle recovery (size and strength) following a disuse period commonly occurs in older adults. Many of these individuals are not able to adequately exercise due to pain and logistic barriers. Thus, nutritional and pharmacological therapeutics, that are translatable, are needed to promote muscle recovery following disuse in older individuals. Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) may be a suitable therapeutic target due to pleiotropic regulation of skeletal muscle. This review focuses on nutritional and pharmacological interventions that target PGC-1α and related Sirtuin 1 (SIRT1) and 5' AMP-activated protein kinase (AMPKα) signaling in muscle and thus may be rapidly translated to prevent muscle disuse atrophy and promote recovery. In this review, we present several therapeutics that target PGC-1α in skeletal muscle such as leucine, β-hydroxy-β-methylbuyrate (HMB), arginine, resveratrol, metformin and combination therapies that may have future application to conditions of disuse and recovery in humans.
在老年人中，长时间不活动后肌肉恢复（大小和力量）受损很常见。由于疼痛和物流障碍，许多人无法进行足够的锻炼。因此，需要可转化的营养和药理学治疗方法来促进老年人不活动后的肌肉恢复。过氧化物酶体增殖物激活受体γ共激活因子 1-α（PGC-1α）可能是一种合适的治疗靶点，因为它对骨骼肌具有多效性调节作用。本综述重点介绍了营养和药理学干预措施，这些措施针对 PGC-1α 及其相关的 Sirtuin 1（SIRT1）和 5' AMP 激活的蛋白激酶（AMPKα）信号在肌肉中的作用，因此可能会被迅速转化，以防止肌肉废用性萎缩并促进恢复。在这篇综述中，我们介绍了几种针对骨骼肌 PGC-1α 的治疗方法，如亮氨酸、β-羟基-β-甲基丁酸盐（HMB）、精氨酸、白藜芦醇、二甲双胍和联合治疗方法，这些方法可能在未来对人类的不活动和恢复条件具有应用前景。
