Semaev Sergey, Shakhtshneider Elena
Institute of Internal and Preventive Medicine-Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Bogatkova Str. 175/1, Novosibirsk 630089, Russia.
Federal Research Center Institute of Cytology and Genetics, SB RAS, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia.
J Pers Med. 2020 Nov 20;10(4):239. doi: 10.3390/jpm10040239.
The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of the circulatory system is due to lifestyle characteristics and associated risk factors. An important and relevant task for the healthcare system is to identify the population segments most susceptible to cardiovascular diseases (CVDs). The level of individual risk of an unfavorable cardiovascular prognosis is determined by genetic factors in addition to lifestyle factors.
本综述涉及冠心病遗传风险评分在不同人群中的创建阶段、计算方法及应用。基于20世纪流行病学研究结果，风险因素的概念已得到普遍认可；根据这一概念，循环系统疾病的高患病率归因于生活方式特征及相关风险因素。医疗保健系统的一项重要且相关的任务是识别最易患心血管疾病（CVD）的人群。除生活方式因素外，心血管不良预后的个体风险水平还由遗传因素决定。
