母乳喂养可恢复剖宫产婴儿的肠道微生物群，并降低其生命早期的感染风险。
Breastfeeding restored the gut microbiota in caesarean section infants and lowered the infection risk in early life.
机构信息
Department of Pediatrics, The Third Hospital of Hebei Medical University, No.139 Ziqiang Road, Shijiazhuang, 050051, China.
Department of Computer Science, City University of Hong Kong, Hong Kong, 999077, China.
出版信息
BMC Pediatr. 2020 Nov 25;20(1):532. doi: 10.1186/s12887-020-02433-x.
BACKGROUND
The initialization of the neonatal gut microbiota (GM) is affected by diverse factors and is associated with infant development and health outcomes.
METHODS
In this study, we collected 207 faecal samples from 41 infants at 6 time points (1, 3, and 7 days and 1, 3, and 6 months after birth). The infants were assigned to four groups according to delivery mode (caesarean section (CS) or vaginal delivery (VD)) and feeding pattern (breastfeeding or formula milk).
RESULTS
The meconium bacterial diversity was slightly higher in CS than in VD. Three GM patterns were identified, including Escherichia/Shigella-Streptococcus-dominated, Bifidobacterium-Escherichia/Shigella-dominated and Bifidobacterium-dominated patterns, and they gradually changed over time. In CS infants, Bifidobacterium was less abundant, and the delay in GM establishment could be partially restored by breastfeeding. The frequency of respiratory tract infection and diarrhoea consequently decreased.
CONCLUSION
This study fills some gaps in the understanding of the restoration of the GM in CS towards that in VD.
背景
新生儿肠道微生物群（GM）的初始状态受到多种因素的影响，与婴儿的发育和健康结果有关。
方法
本研究收集了 41 名婴儿在 6 个时间点（出生后 1、3、7 天和 1、3、6 个月）的 207 份粪便样本。根据分娩方式（剖宫产（CS）或阴道分娩（VD））和喂养方式（母乳喂养或配方奶）将婴儿分为四组。
结果
CS 婴儿的胎粪细菌多样性略高于 VD 婴儿。确定了三种 GM 模式，包括大肠杆菌/志贺氏菌-链球菌占主导、双歧杆菌-大肠杆菌/志贺氏菌占主导和双歧杆菌占主导模式，并且它们随时间逐渐变化。在 CS 婴儿中，双歧杆菌的丰度较低，母乳喂养可以部分恢复 GM 的建立延迟。呼吸道感染和腹泻的频率因此降低。
结论
本研究填补了对 CS 婴儿 GM 向 VD 婴儿 GM 恢复的理解中的一些空白。
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