Horváth Péter, Müller-Reichert Thomas
Experimental Center, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Front Cell Dev Biol. 2020 Nov 9;8:586880. doi: 10.3389/fcell.2020.586880. eCollection 2020.
The endosomal sorting complex required for transport (ESCRT) mediates cellular processes that are related to membrane remodeling, such as multivesicular body (MVB) formation, viral budding and cytokinesis. Abscission is the final stage of cytokinesis that results in the physical separation of the newly formed two daughter cells. Although abscission has been investigated for decades, there are still fundamental open questions related to the spatio-temporal organization of the molecular machinery involved in this process. Reviewing knowledge obtained from as well as experiments, we give a brief overview on the role of ESCRT components in abscission mainly focussing on mammalian cells.
转运所需的内体分选复合体（ESCRT）介导与膜重塑相关的细胞过程，如多泡体（MVB）形成、病毒出芽和胞质分裂。胞质分裂的最后阶段是切割，它导致新形成的两个子细胞的物理分离。尽管对切割的研究已有数十年，但与此过程中涉及的分子机制的时空组织相关的基本开放性问题仍然存在。回顾从[具体实验名称1]以及[具体实验名称2]实验中获得的知识，我们简要概述了ESCRT组分在切割中的作用，主要聚焦于哺乳动物细胞。
