年龄相关性衰弱：老年科学的临床模型？

Age-Related Frailty: A Clinical Model for Geroscience?

作者信息

Takeda C, Angioni D, Setphan E, Macaron T, De Souto Barreto P, Sourdet S, Sierra F, Vellas B

机构信息

Dr Catherine Takeda, MD, Gérontopôle, CHU Toulouse, Cité de la Santé, Hôpital La Grave, Place Lange, 31059 Toulouse cedex 9, France, Tel : +33.(0)5.17.77.70.28, Fax +33.(0)5.61.77.70.71, E-mail :

出版信息

J Nutr Health Aging. 2020;24(10):1140-1143. doi: 10.1007/s12603-020-1491-4.

DOI:10.1007/s12603-020-1491-4

PMID:33244574

Abstract

In their everyday practice, geriatricians are confronted with the fact that older age and multimorbidity are associated to frailty. Indeed, if we take the example of a very old person with no diseases that progressively becomes frail with no other explanation, there is a natural temptation to link frailty to aging. On the other hand, when an old person with a medical history of diabetes, arthritis and congestive heart failure becomes frail there appears an obvious relationship between frailty and comorbidity. The unsolved question is: Considering that frailty is multifactorial and in the majority of cases comorbidity and aging are acting synergistically, can we disentangle the main contributor to the origin of frailty: disease or aging? We believe that it is important to be able to differentiate age-related frailty from frailty related to comorbidity. In fact, with the emergence of geroscience, the physiopathology, diagnosis, prognosis and treatment will probably have to be different in the future.

摘要

在日常临床工作中，老年医学专家面临着这样一个事实：高龄和多种疾病并存与衰弱相关。的确，如果以一个没有疾病的非常年长者为例，其逐渐变得衰弱且没有其他原因，人们自然会倾向于将衰弱与衰老联系起来。另一方面，当一个有糖尿病、关节炎和充血性心力衰竭病史的老年人变得衰弱时，衰弱与共病之间就存在明显的关联。尚未解决的问题是：鉴于衰弱是多因素的，且在大多数情况下共病和衰老协同起作用，我们能否厘清导致衰弱的主要因素：疾病还是衰老？我们认为，能够区分与年龄相关的衰弱和与共病相关的衰弱很重要。事实上，随着老年科学（geroscience）的出现，未来生理病理学、诊断、预后和治疗可能都将有所不同。