Sutker P B, Goist K C, Allain A N, Bugg F
Psychology Service, Veterans Administration Medical Center, New Orleans, Louisiana 70146.
Alcohol Clin Exp Res. 1987 Dec;11(6):507-12. doi: 10.1111/j.1530-0277.1987.tb00162.x.
This study explored sex differences in pharmacokinetic and mood state responses to acute alcohol intoxication among socially drinking women demonstrated to be normally cycling across two consecutive menstrual cycles and men with similar drinking habits. Subjects were administered moderate or high alcohol doses in six experimental sessions over a 60-day period. Women were tested during the early follicular, ovulatory, and midluteal phases of the cycle, and men were administered alcohol at comparable time intervals. Results showed that men did not differ in alcohol pharmacokinetics across sessions, but women showed significantly shorter elimination times and faster disappearance rates during the midluteal phase of the menstrual cycle compared to the early follicular and ovulatory phases and to their male counterparts. There were no sex or within-group differences in self-reported negative mood states prior to alcohol administration, but women described increased anxiety and depression while intoxicated during the early follicular compared to ovulatory and midluteal phases. Affective responses to intoxication were a complex function of sex, limb of the blood alcohol concentration-time curve, and dose.
本研究探讨了在社交场合饮酒的女性和有相似饮酒习惯的男性中，急性酒精中毒后药代动力学和情绪状态反应的性别差异。这些女性在连续两个月经周期中月经周期正常。在60天内的六个实验环节中，受试者被给予中等或高剂量酒精。女性在月经周期的卵泡早期、排卵期和黄体中期接受测试，男性在相应的时间间隔接受酒精给药。结果显示，男性在各环节的酒精药代动力学无差异，但与卵泡早期、排卵期及男性相比，女性在月经周期黄体中期的消除时间显著缩短，消失速率更快。饮酒前自我报告的负面情绪状态不存在性别或组内差异，但与排卵期和黄体中期相比，女性在卵泡早期饮酒时描述的焦虑和抑郁情绪增加。对中毒的情感反应是性别、血酒精浓度-时间曲线阶段和剂量的复杂函数。
