Khanal Pukar, Duyu Taaza, Patil B M, Dey Yadu Nandan, Pasha Ismail, Wanjari Manish, Gurav Shailendra S, Maity Arindam
Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010, India.
Department of Pharmacology and Toxicology, KLE College of Pharmacy Belagavi, KLE Academy of Higher Education and Research (KAHER), Belagavi, 590010, India.
J Ayurveda Integr Med. 2022 Jan-Mar;13(1):100374. doi: 10.1016/j.jaim.2020.11.004. Epub 2020 Nov 25.
The Ministry of AYUSH recommended the use of a decoction of the mixture of , , , and as a preventive measure by boosting the immunity against the severity of infection caused by a novel coronavirus (COVID-19). The present study aimed to identify the probable modulated pathways by the combined action of AYUSH recommended herbal tea and golden milk formulation as an immune booster against COVID-19. Reported phytoconstituents of all the medicinal plants were retrieved from the ChEBI database, and their targets were predicted using DIGEP-Pred. STRING database and Cytoscape were used to predict the protein-protein interaction and construct the network, respectively. Likewise, MolSoft and admet SAR2.0 were used to predict the druglikeness score and ADMET profile of phytoconstituents. The study identified the modulation of HIF-1, p53, PI3K-Akt, MAPK, cAMP, Ras, Wnt, NF- B, IL-17, TNF, and cGMP-PKG signaling pathways to boost the immune system. Further, multiple pathways were also identified which are involved in the regulation of pathogenesis of the multiple infections and non-infectious diseases due to the lower immune system. Results indicated that he recommended herbal formulation not only modulated the pathways involved in boosting the immunity but also modulated the multiple pathways that are contributing to the progression of multiple disease pathogenesis which would add the beneficial effect in the co-morbid patients of hypertension and diabetes. The study provides the scientific documentation of the role of the Ayurvedic formulation to combat COVID-19.
阿育吠陀部建议使用由[具体草药1]、[具体草药2]、[具体草药3]、[具体草药4]和[具体草药5]混合而成的汤剂作为预防措施，通过增强对新型冠状病毒（COVID-19）引起的感染严重性的免疫力来预防感染。本研究旨在确定阿育吠陀部推荐的草药茶和黄金奶配方联合作用作为针对COVID-19的免疫增强剂可能调节的途径。从ChEBI数据库中检索了所有药用植物已报道的植物化学成分，并使用DIGEP-Pred预测其靶点。分别使用STRING数据库和Cytoscape预测蛋白质-蛋白质相互作用并构建网络。同样，使用MolSoft和admet SAR2.0预测植物化学成分的类药性质得分和ADMET概况。该研究确定了对缺氧诱导因子-1（HIF-1）、p53、磷脂酰肌醇-3激酶-蛋白激酶B（PI3K-Akt）、丝裂原活化蛋白激酶（MAPK）、环磷酸腺苷（cAMP）、Ras、Wnt、核因子κB（NF-κB）、白细胞介素-17（IL-17）、肿瘤坏死因子（TNF）和环磷酸鸟苷-蛋白激酶G（cGMP-PKG）信号通路的调节以增强免疫系统。此外，还确定了多个因免疫系统低下而参与多种感染和非感染性疾病发病机制调节的途径。结果表明，推荐的草药配方不仅调节了参与增强免疫力的途径，还调节了多个导致多种疾病发病机制进展的途径，这将对高血压和糖尿病合并症患者产生有益影响。该研究为阿育吠陀配方对抗COVID-19的作用提供了科学依据。
